Early life programming and neurodevelopmental disorders.
Early life programming and neurodevelopmental disorders.
复制标题
早期生活节目和神经发育障碍。
DOI：
10.1016/j.biopsych.2010.05.028
复制
发表时间：
2010-08-15
影响因子：
10.6
通讯作者：
Nestler, Eric J.
中科院分区：
文献类型：
--
作者：
Bale, Tracy L.;Baram, Tallie Z.;Brown, Alan S.;Goldstein, Jill M.;Insel, Thomas R.;McCarthy, Margaret M.;Nemeroff, Charles B.;Reyes, Teresa M.;Simerly, Richard B.;Susser, Ezra S.;Nestler, Eric J.
世纪以来，临床研究者一直把早期生活作为成人精神病理学的一个来源。早期关于心理冲突和有害的父母教养的理论已经被基因和环境复杂相互作用的新理论所取代。虽然假设的机制已经演变，但一个中心概念仍然存在：早期生活是一个独特的敏感期，在此期间，经验赋予持久的影响。这些影响的机制在今天仍然像世纪前一样是一个谜。最近的研究表明，母亲的饮食可以规划后代的生长和代谢途径，改变终身对糖尿病和肥胖的易感性。如果母亲的社会心理经验对发育中的后代有类似的编程影响，那么人们可能会期望对神经发育障碍（包括情感障碍、精神分裂症、自闭症和饮食障碍）有类似的贡献。根据世界卫生组织2002年的报告，由于这些疾病发病早、普遍和慢性，其中一些疾病，如抑郁症和精神分裂症，是全世界残疾的最高原因。考虑到早期生活编程和转录调控成人暴露支持一个关键的需要，了解表观遗传机制作为一个关键的决定因素，在疾病易感性。下面的综述总结了2009年在宾夕法尼亚大学举行的关于早期生活编程和神经发育障碍的研讨会的结果，阐述了从临床和流行病学研究中获得的最新见解，以及从基础研究中获得的潜在表观遗传机制。
For more than a century, clinical investigators have focused on early life as a source of adult psychopathology. Early theories about psychic conflict and toxic parenting have been replaced by more recent formulations of complex interactions of genes and environment. Although the hypothesized mechanisms have evolved, a central notion remains: early life is a period of unique sensitivity during which experience confers enduring effects. The mechanisms for these effects remain almost as much a mystery today as they were a century ago. Recent studies suggest that maternal diet can program offspring growth and metabolic pathways, altering lifelong susceptibility to diabetes and obesity. If maternal psychosocial experience has similar programming effects on the developing offspring, one might expect a comparable contribution to neurodevelopmental disorders, including affective disorders, schizophrenia, autism, and eating disorders. Due to their early onset, prevalence, and chronicity, some of these disorders, such as depression and schizophrenia, are among the highest causes of disability worldwide according to the World Health Organization 2002 report. Consideration of the early life programming and transcriptional regulation in adult exposures supports a critical need to understand epigenetic mechanisms as a critical determinant in disease predisposition. Incorporating the latest insight gained from clinical and epidemiological studies with potential epigenetic mechanisms from basic research, the following review summarizes findings from a workshop on Early Life Programming and Neurodevelopmental Disorders held at the University of Pennsylvania in 2009.
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DOI：
10.1523/jneurosci.3021-09.2010
发表时间：
2010-01-13
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Goldstein JM;Jerram M;Abbs B;Whitfield-Gabrieli S;Makris N
通讯作者：
Makris N
DOI：
10.1523/jneurosci.0097-09.2009
发表时间：
2009-06-24
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Akhtar MW;Raingo J;Nelson ED;Montgomery RL;Olson EN;Kavalali ET;Monteggia LM
通讯作者：
Monteggia LM
影响因子：
2.7
作者：
Bilbo, SD;Rudy, JW;Maier, SF
通讯作者：
Maier, SF
影响因子：
120.7
作者：
Binder, Elisabeth B.;Bradley, Rebekah G.;Ressler, Kerry J.
通讯作者：
Ressler, Kerry J.
影响因子：
15.1
作者：
Buka, SL;Tsuang, MT;Yolken, RH
通讯作者：
Yolken, RH