Insulin/IGF Axis in Breast Cancer: Clinical Evidence and Translational Insights.
Insulin/IGF Axis in Breast Cancer: Clinical Evidence and Translational Insights.
复制标题
DOI：
10.3390/biom11010125
复制
发表时间：
2021-01-19
期刊：
影响因子：
5.5
通讯作者：
Gennari A
中科院分区：
文献类型：
--
作者：
Biello F;Platini F;D'Avanzo F;Cattrini C;Mennitto A;Genestroni S;Martini V;Marzullo P;Aimaretti G;Gennari A
背景：乳腺癌（BC）是女性最常见的肿瘤。许多临床和临床前研究调查了宿主代谢与BC之间的可能关系。已报道BC亚型之间的葡萄糖代谢存在显著差异。胰岛素可通过对上皮组织的直接作用或通过影响其他调节剂（如胰岛素样生长因子（IGF）受体家族、性激素和脂肪因子）的水平间接促进肿瘤发生。二甲双胍的潜在抗癌活性基于两个主要作用：第一，其降低循环胰岛素水平的能力，具有可能影响肿瘤细胞增殖的间接内分泌作用;第二，其对许多促癌信号通路的直接影响，这些通路是BC侵袭性的关键驱动因素。研究方法：在目前的审查中，BC，宿主代谢和患者的预后之间的相互作用已经审查了现有的文献证据。结论：肥胖、代谢综合征和胰岛素抵抗均参与了BC的生长，并可能对预后产生相关影响。所有这些因素都通过促炎状态起作用，由脂肪组织中产生的细胞因子介导，并且似乎与BC发展的更高风险和更差的预后有关。
Background: Breast cancer (BC) is the most common neoplasm in women. Many clinical and preclinical studies investigated the possible relationship between host metabolism and BC. Significant differences among BC subtypes have been reported for glucose metabolism. Insulin can promote tumorigenesis through a direct effect on epithelial tissues or indirectly by affecting the levels of other modulators, such as the insulin-like growth factor (IGF) family of receptors, sex hormones, and adipokines. The potential anti-cancer activity of metformin is based on two principal effects: first, its capacity for lowering circulating insulin levels with indirect endocrine effects that may impact on tumor cell proliferation; second, its direct influence on many pro-cancer signaling pathways that are key drivers of BC aggressiveness. Methods: In the present review, the interaction between BC, host metabolism, and patients’ prognosis has been reviewed across available literature evidence. Conclusions: Obesity, metabolic syndrome, and insulin resistance are all involved in BC growth and could have a relevant impact on prognosis. All these factors act through a pro-inflammatory state, mediated by cytokines originated in fat tissue, and seem to be related to a higher risk of BC development and worse prognosis.
登录
查看更多内容
DOI：
10.1093/annonc/mdu042
发表时间：
2014-10
期刊：
Annals of oncology : official journal of the European Society for Medical Oncology
影响因子：
--
作者：
Chan DSM;Vieira AR;Aune D;Bandera EV;Greenwood DC;McTiernan A;Navarro Rosenblatt D;Thune I;Vieira R;Norat T
通讯作者：
Norat T
影响因子：
3.8
作者：
Gennari, Alessandra;Foca, Flavia;Nanni, Oriana
通讯作者：
Nanni, Oriana
影响因子：
3.8
作者：
Gaudet MM;Press MF;Haile RW;Lynch CF;Glaser SL;Schildkraut J;Gammon MD;Douglas Thompson W;Bernstein JL
通讯作者：
Bernstein JL
影响因子：
3.2
作者：
Alan, Ozkan;Akin Telli, Tugba;Yumuk, Perran Fulden
通讯作者：
Yumuk, Perran Fulden
影响因子：
6.4
作者：
Iqbal, Jabed;Thike, Aye Aye;Tan, Puay Hoon
通讯作者：
Tan, Puay Hoon