Salivary Biomarkers-A Review of Powerful Diagnostic tool
Salivary Biomarkers-A Review of Powerful Diagnostic tool
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唾液生物标志物——强大诊断工具的回顾
DOI：
10.6084/m9.figshare.1384292.v1
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
L. Dr.
中科院分区：
文献类型：
--
作者：
Journals Iosr;Goswami Dr.Yogesh;R. M. Dr.;A. Dr.;L. Dr.
任何疾病的早期发现在成功治疗中起着重要作用。早期诊断和治疗可降低疾病活动的严重程度和可能的并发症。人类的唾液不仅仅是我们口中的液体，它还反映了我们身体的健康和福祉。在血液中循环的生物分子也存在于人类唾液中。它由大约2，000种蛋白质组成，其中26%的蛋白质也存在于血液中，因此它强调了唾液作为疾病诊断和监测的附加生物资源的重要性，以及确定一个人对治疗的反应的最终诊断介质。确定生物标志物以筛选和预测疾病的早期发作（预后测试）或评估疾病的活动性和治疗效果（诊断测试）一直是牙周病学的巨大挑战。传统的诊断方法，如牙周袋深度、附着水平、菌斑指数、探诊出血和牙槽骨丢失的放射学评估，不一定是早期诊断的最有效方法。如今，临床椅旁试验用于更精确的分子诊断和治疗。一种简单和非侵入性的诊断工具，可以快速筛查，提供准确的预测信息，并能够可靠地评估牙周病的状态，这将是非常有价值的牙医和病人。唾液诊断（SD）领域始于60年代初，当时发现囊性纤维化患者的唾液钙水平升高，并且自那时起50年来，由于日益灵敏的检测技术的发展，该领域已经发展到无法预测的距离。因此，在纳米技术和基因组学时代的今天，唾液诊断领域有望在疾病诊断和临床监测方面发生巨大变化。它已经扩展到检测癌症，心脏病和
Early detection of any disease plays an important role in successful treatment. Early diagnosis and treatment reduces the severity and possible complications of disease activity. Human saliva is not just a fluid in our mouth, but it mirrors our body's health and well-being. Biomolecules that are circulating in the blood are also found in human saliva. It consists of approximately about 2,000 proteins, and 26% of these proteins are also found in blood, therefore it emphasizes saliva's importance as an added biological resource for disease diagnosis and monitoring, as well as an ultimate diagnostic medium to establish a person's response to treatment. It has been a great challenge in periodontologyto determine biomarkers for screening and predicting the early onset of disease (prognostic tests) or evaluating the disease activity and the efficacy of therapy (diagnostic tests). Traditional diagnostic measures, such as periodontal pocket depth, attachment level, plaque index, bleeding on probing and radiographic assessment of alveolar bone loss, are not necessarily the most efficient method for early diagnosis.Nowadays, clinical chairside tests are in use for more precise molecular diagnostics and treatments.A simple and non-invasive diagnostic tool that allows rapid screening, provides accurate predictive information and enables reliable evaluation of periodontal disease status would be of great value to both dentists and patients. The field of saliva diagnostics (SDs) began in the early 60s when salivary calcium levels were found to be elevated in cystic fibrosis patients, and 50 years since then how the field has unmitigated to an unpredicted distance due to the development of increasingly sensitive detection techniques. Hence, today in the era of nanotechnology and genomics, field of salivary diagnostics is promising a dramatic change in disease diagnosis and clinical monitoring. It has expanded into detection of cancer, heart and
唾液：一种用于早期检测疾病的新兴生物流体。
影响因子：
1.4
作者：
Lee,Yu-Hsiang;Wong,DavidT
通讯作者：
Wong,DavidT
影响因子：
6.1
作者：
Liu C;Qiu X;Ongagna S;Chen D;Chen Z;Abrams WR;Malamud D;Corstjens PL;Bau HH
通讯作者：
Bau HH
影响因子：
4.4
作者：
Bandhakavi, Sricharan;Stone, Matthew D.;Onsongo, Getiria;Van Riper, Susan K.;Griffin, Timothy J.
通讯作者：
Griffin, Timothy J.