A review of odd-chain fatty acid metabolism and the role of pentadecanoic Acid (c15:0) and heptadecanoic Acid (c17:0) in health and disease.
A review of odd-chain fatty acid metabolism and the role of pentadecanoic Acid (c15:0) and heptadecanoic Acid (c17:0) in health and disease.
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DOI：
10.3390/molecules20022425
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发表时间：
2015-01-30
期刊：
影响因子：
--
通讯作者：
Koulman A
中科院分区：
文献类型：
--
作者：
Jenkins B;West JA;Koulman A
C17：0和C15：0在人类健康中的作用最近在一些重要的生物学和营养学观察之后得到了加强。历史上，奇数链饱和脂肪酸（OCS-FA）被用作总脂肪酸GC-MS方法和完整脂质LC-MS方法的内标物，因为认为其在人体中的浓度不显著。然而，人们认为乳制品消费量的增加与血浆OCS-FA的增加有关。然而，目前还没有直接的证据，而是通过流行病学研究的因果关系。此外，许多关于心脏代谢疾病的研究表明，OCS-FA的血浆浓度与较低的疾病风险相关，尽管对此负责的机制存在争议。内源性产生OCS-FA的一种可能机制是α-氧化，包括活化，然后羟基化α-碳，然后去除末端羧基。分化的人脂肪细胞中OCS-FAs的浓度明显升高，这可能是通过α-氧化引起的。内源性途径的进一步证据是在人血浆中，其中C15：0与C17：0的比例约为1：2，这与在乳制品脂肪中检测到的C15：0至C17：0的预期水平（约为2：1）相矛盾。我们回顾了有关OCS-FAs的饮食消费及其潜在内源性代谢的文献。
The role of C17:0 and C15:0 in human health has recently been reinforced following a number of important biological and nutritional observations. Historically, odd chain saturated fatty acids (OCS-FAs) were used as internal standards in GC-MS methods of total fatty acids and LC-MS methods of intact lipids, as it was thought their concentrations were insignificant in humans. However, it has been thought that increased consumption of dairy products has an association with an increase in blood plasma OCS-FAs. However, there is currently no direct evidence but rather a casual association through epidemiology studies. Furthermore, a number of studies on cardiometabolic diseases have shown that plasma concentrations of OCS-FAs are associated with lower disease risk, although the mechanism responsible for this is debated. One possible mechanism for the endogenous production of OCS-FAs is α-oxidation, involving the activation, then hydroxylation of the α-carbon, followed by the removal of the terminal carboxyl group. Differentiation human adipocytes showed a distinct increase in the concentration of OCS-FAs, which was possibly caused through α-oxidation. Further evidence for an endogenous pathway, is in human plasma, where the ratio of C15:0 to C17:0 is approximately 1:2 which is contradictory to the expected levels of C15:0 to C17:0 roughly 2:1 as detected in dairy fat. We review the literature on the dietary consumption of OCS-FAs and their potential endogenous metabolism.
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影响因子：
15.9
作者：
FERRANNINI, E;BARRETT, EJ;DEFRONZO, RA
通讯作者：
DEFRONZO, RA
DOI：
10.5713/ajas.2011.11146
发表时间：
2012-01-01
期刊：
ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES
影响因子：
--
作者：
Dohme-Meier, F.;Bee, G.
通讯作者：
Bee, G.
影响因子：
3.2
作者：
Dijkstra, J.;van Zijderveld, S. M.;Berends, H.
通讯作者：
Berends, H.
影响因子：
3.2
作者：
Fievez, V.;Colman, E.;Vlaeminck, B.
通讯作者：
Vlaeminck, B.
影响因子：
3.7
作者：
Hellmuth C;Demmelmair H;Schmitt I;Peissner W;Blüher M;Koletzko B
通讯作者：
Koletzko B