Association between plasma nonesterified fatty acids species and adipose tissue fatty acid composition.
Association between plasma nonesterified fatty acids species and adipose tissue fatty acid composition.
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DOI：
10.1371/journal.pone.0074927
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Koletzko B
中科院分区：
文献类型：
--
作者：
Hellmuth C;Demmelmair H;Schmitt I;Peissner W;Blüher M;Koletzko B
脂肪组织的脂肪酸组成（AT）是脂肪酸（FA）摄入和状态的既定长期生物标志物，但AT样本不易获得。血浆脂肪酸非酯化组成（pNEFA）可能是一个很好的指标，因为pNEFA主要由AT脂肪分解产生。我们研究了27名中位BMI为36 kg/m2的非糖尿病女性（Q0.25：25 kg/m2; Q0.75：49 kg/m2）的42 pNEFA与皮下和内脏AT FA的相关性。奇链脂肪酸（皮下和内脏AT为15 ∶ 0，r = 0.838和0.862）和ω-3脂肪酸（22 ∶ 6，r = 0.719/0.535）与AT脂肪酸密切相关，而其它脂肪酸（18 ∶ 1，r = 0.384/0.325）和20 ∶ 4，r = 0.386/0.266）与pNEFA无显著或低度相关。 必需脂肪酸的pNEFA与ATFA呈显著正相关，分别为18 ∶ 2（r = 0.541/0.610）和20 ∶ 5（r = 0.561/0.543）。 一些pNEFA种类与AT FA的相关性较低，表明除了AT释放外，大多数pNEFA的变化还受到其他FA来源和FA向组织的通量的显著影响。BMI对饱和脂肪酸的相关性水平有相关影响。空腹血浆中的NEFA分析可以作为某些FA的虚拟AT活检，并作为乳制品和海鱼摄入的生物标志物。
Fatty acid composition of adipose tissue (AT) is an established long-term biomarker for fatty acid (FA) intake and status, but AT samples are not easily available. Nonesterified FA composition in plasma (pNEFA) may be a good indicator of AT FA composition, because pNEFA are mainly generated by AT lipolysis. We investigated the correlation of 42 pNEFA and subcutaneous as well as visceral AT FA in 27 non-diabetic women with a median BMI of 36 kg/m2 (Q0.25: 25 kg/m2; Q0.75: 49 kg/m2). Close correlations of pNEFA and AT FA were found for odd-chain FA (15∶0 r = 0.838 and 0.862 for subcutaneous and visceral AT, respectively) and omega-3 FA (22∶6 r = 0.719/0.535), while no significant or low correlations were found for other FA including 18∶1 (r = 0.384/0.325) and 20∶4 (r = 0.386/0.266). Close correlations of pNEFA and AT FA were found for essential fatty acids, like 18∶2 (r = 0.541/0.610) and 20∶5 (r = 0.561/0.543). The lower correlation for some pNEFA species with AT FA indicates that the variation of most pNEFA is significantly affected by other FA sources and flux of FA to tissue, in addition to release from AT. A relevant influence of BMI on the level of correlation was shown for saturated FA. NEFA analysis in fasted plasma can serve as a virtual AT biopsy for some FA, and as a biomarker for intake of dairy products and sea fish.
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DOI：
10.1080/09637480701425650
发表时间：
2009-01-01
影响因子：
3.9
作者：
Ozogul, Yesim;Ozogul, Fatih;Kuley, Esmeray
通讯作者：
Kuley, Esmeray
影响因子：
3.3
作者：
Mansson, Helena Lindmark
通讯作者：
Mansson, Helena Lindmark
影响因子：
7.7
作者：
Koutsari C;Mundi MS;Ali AH;Jensen MD
通讯作者：
Jensen MD
影响因子：
4.4
作者：
Kim, Hyun-Jin;Kim, Jin Hee;Yoon, Suk Hoo
通讯作者：
Yoon, Suk Hoo
影响因子：
7.1
作者：
Baylin, A;Kabagambe, EK;Campos, H
通讯作者：
Campos, H