Optic nerve head morphology in glaucoma patients of African descent is strongly correlated to retinal blood flow.
Optic nerve head morphology in glaucoma patients of African descent is strongly correlated to retinal blood flow.
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DOI：
10.1136/bjophthalmol-2013-304393
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发表时间：
2014-11
期刊：
影响因子：
--
通讯作者：
Abrams Tobe L
中科院分区：
文献类型：
--
作者：
Kanakamedala P;Harris A;Siesky B;Tyring A;Muchnik M;Eckert G;Abrams Tobe L
目的探讨非洲裔(AD)和欧洲裔(ED)开角型青光眼(OAG)患者3年来视神经头(ONH)形态改变与视网膜血流的关系。112例OAG患者(29例AD，83例ED)采用海德堡视网膜断层扫描(HRT-III)和激光共聚焦扫描多普勒对ONH的形态和视网膜血流进行了评估。用重复测量协方差分析比较基线和3年测量结果，并计算皮尔逊相关系数以评估两者之间的关系。在AD的OAG患者中，上平均视网膜血流量的变化与视杯/视盘(C/D)面积比(r=−0.78，p=0.020)和视杯面积(r=−0.75，p=0.0283)的变化呈显著负相关，与视网膜边缘面积的变化(r=0.74，p=0.0328)呈显著正相关。在AD的OAG患者中，下平均视网膜血流量的变化与三年来C/D面积比(r=−0.88，p=0.0156)和线性C/D比(r=−0.86，p=0.0265)的变化呈显著负相关。在ED的OAG患者中，这些相关性较弱，未达到统计学意义。OAG AD患者的青光眼病理生理可能比ED患者具有更强的血管成分。
To examine the relationship between change in optic nerve head (ONH) morphology and retinal blood flow in patients with open-angle glaucoma (OAG) of African (AD) and European descent (ED) over three years. 112 patients with OAG (29 AD; 83 ED) underwent assessment of ONH morphology using Heidelberg retinal tomography (HRT-III) and retinal blood flow using confocal scanning laser Doppler. Repeated measures analysis of covariance was used to compare baseline and 3-year measurements and Pearson correlations were calculated to evaluate the relationships. In OAG patients of AD, change in superior mean retinal blood flow was strongly, negatively correlated with change in cup/disc (C/D) area ratio (r=−0.78, p=0.020) and cup area (r=−0.75, p=0.0283) and strongly, positively correlated with change in rim area (r=0.74, p=0.0328) over three years. In OAG patients of AD, change in inferior mean retinal blood flow was strongly, negatively correlated with changes in C/D area ratio (r=−0.88, p=0.0156) and linear C/D ratio (r=−0.86, p=0.0265) over three years. In OAG patients of ED, these correlations were weak and did not reach statistical significance. OAG patients of AD may have a stronger vascular component to their glaucoma pathophysiology than patients of ED.
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影响因子：
37.8
作者：
Roger VL;Go AS;Lloyd-Jones DM;Benjamin EJ;Berry JD;Borden WB;Bravata DM;Dai S;Ford ES;Fox CS;Fullerton HJ;Gillespie C;Hailpern SM;Heit JA;Howard VJ;Kissela BM;Kittner SJ;Lackland DT;Lichtman JH;Lisabeth LD;Makuc DM;Marcus GM;Marelli A;Matchar DB;Moy CS;Mozaffarian D;Mussolino ME;Nichol G;Paynter NP;Soliman EZ;Sorlie PD;Sotoodehnia N;Turan TN;Virani SS;Wong ND;Woo D;Turner MB;American Heart Association Statistics Committee and Stroke Statistics Subcommittee
通讯作者：
American Heart Association Statistics Committee and Stroke Statistics Subcommittee
影响因子：
--
作者：
Higginbotham, EJ;Gordon, MO;Kass, MA
通讯作者：
Kass, MA
影响因子：
4.2
作者：
MARTIN, MJ;SOMMER, A;DIAMOND, EL
通讯作者：
DIAMOND, EL
影响因子：
158.5
作者：
SOMMER, A;TIELSCH, JM;EZRINE, S
通讯作者：
EZRINE, S
DOI：
10.3129/i08-051
发表时间：
2008-06-01
影响因子：
4.2
作者：
Harris, Alon;Kagemann, Larry;Siesky, Brent
通讯作者：
Siesky, Brent