Polycyclic aromatic hydrocarbon exposure and wheeze in a cohort of children with asthma in Fresno, CA.
Polycyclic aromatic hydrocarbon exposure and wheeze in a cohort of children with asthma in Fresno, CA.
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DOI：
10.1038/jes.2012.29
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发表时间：
2012-07
影响因子：
4.5
通讯作者：
中科院分区：
文献类型：
--
作者：
多环芳烃（PAHs）广泛存在于环境空气中，是各种燃料燃烧和工业过程的产物。多环芳烃与人类健康的不利影响有关，如认知发展，儿童智商和呼吸系统健康。弗雷斯诺哮喘儿童环境研究（FACES）在加利福尼亚州弗雷斯诺招募了315名6-11岁的哮喘儿童，并在2000年至2008年期间对该队列进行了随访。受试者每年最多接受3次为期14天的哮喘症状评估。详细的环境污染物浓度收集从一个中心站点和室外污染物进行了测量，在83个家庭至少一个5天的时间。颗粒结合的多环芳烃的测量与土地利用回归模型，估计个人暴露于多环芳烃与4-，5-或6-成员环（PAH 456）和菲的队列（约22 000个人每天估计）。我们使用了交叉验证为基础的算法模型拟合和广义估计方程的方法来解释重复测量。PAH暴露的多重滞后和移动平均值与三种PAH暴露估计值中每一种的喘息增加相关。暴露于多环芳烃（ng/m3）的哮喘患者的比值比范围为1.01（95%CI，1.00-1.02）至1.10（95%CI，1.04-1.17）。在所有测量的多环芳烃中，这种喘息增加的趋势持续存在。菲被发现有较高的相对影响喘息。这些数据提供了进一步的证据表明，多环芳烃有助于哮喘发病率。
Polycyclic aromatic hydrocarbons (PAHs) are found widely in the ambient air and result from combustion of various fuels and industrial processes. PAHs have been associated with adverse human health effects such as cognitive development, childhood IQ, and respiratory health. The Fresno Asthmatic Children’s Environment Study (FACES) enrolled 315 children ages 6-11 years with asthma in Fresno, CA and followed the cohort from 2000 to 2008. Subjects were evaluated for asthma symptoms in up to three 14-day panels per year. Detailed ambient pollutant concentrations were collected from a central site and outdoor pollutants were measured at 83 homes for at least one 5-day period. Measurements of particle-bound PAHs were used with land use regression models to estimate individual exposures to PAHs with 4-, 5- or 6-member rings (PAH456) and phenanthrene for the cohort (approximately 22 000 individual daily estimates). We used a cross-validation based algorithm for model fitting and a generalized estimated equation approach to account for repeated measures. Multiple lags and moving averages of PAH exposure were associated with increased wheeze for each of the three types of PAH exposure estimates. The odds ratios for asthmatics exposed to PAHs (ng/m3) ranged from 1.01 (95% CI, 1.00-1.02) to 1.10 (95% CI, 1.04-1.17)]. This trend for increased wheeze persisted among all PAHs measured. Phenanthrene was found to have a higher relative impact on wheeze. These data provide further evidence that PAHs contribute to asthma morbidity.
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影响因子：
4.7
作者：
Ma L;Shima M;Yoda Y;Yamamoto H;Nakai S;Tamura K;Nitta H;Watanabe H;Nishimuta T
通讯作者：
Nishimuta T
影响因子：
10.4
作者：
Jerrett M;Finkelstein MM;Brook JR;Arain MA;Kanaroglou P;Stieb DM;Gilbert NL;Verma D;Finkelstein N;Chapman KR;Sears MR
通讯作者：
Sears MR
影响因子：
9.8
作者：
Briggs, DJ;de Hoogh, C;Smallbone, K
通讯作者：
Smallbone, K
影响因子：
10.4
作者：
Delfino, Ralph J.;Staimer, Norbert;Sioutas, Constantinos
通讯作者：
Sioutas, Constantinos
影响因子：
10.4
作者：
Delfino RJ
通讯作者：
Delfino RJ