Biodistribution and dosimetry of an aqueous solution containing sodium 3-(125I)iodo-4-hydroxybenzenesulfonate (Iotrex) for brachytherapy of resected malignant brain tumors.
Biodistribution and dosimetry of an aqueous solution containing sodium 3-(125I)iodo-4-hydroxybenzenesulfonate (Iotrex) for brachytherapy of resected malignant brain tumors.
复制标题
含有 3-(125I)碘-4-羟基苯磺酸钠 (Iotrex) 的水溶液用于切除恶性脑肿瘤近距离治疗的生物分布和剂量测定。
DOI：
10.1089/cbr.2000.15.645
复制
发表时间：
2000
影响因子：
3.4
通讯作者：
J. Williams
中科院分区：
文献类型：
--
作者：
J. Stubbs;A. Strickland;R. Frank;J. Simon;K. Mcmillan;J. Williams
无标签
Iotrex 是一种含有 3-(125I)碘-4-羟基苯磺酸钠 (125I-HBS) 的放射治疗水溶液，用作使用 GliaSite 导管切除脑肿瘤腔边缘的近距离放射治疗的放射源。在这种近距离放射治疗施用器和放射源的常规临床使用过程中，大约 0.1% 的后载 Iotrex 将通过 GliaSite 球囊扩散。我们的目的是评估 GliaSite 常规临床使用下对正常器官的辐射剂量。
方法
五组大鼠接受 131I-HBS 溶液脑内注射（131I 在合成 125I-HBS 中用作 125I 的替代品），其中一组在给药后 15 分钟、30 分钟、1 小时、2 小时和 4 小时处死。收集尿液并测量许多器官的活性保留。生物分布数据用于估计参考成年男性和女性体模正常器官的辐射剂量。
结果
放射性物质从大脑（2 小时清除 98%）和全身（尿液清除；2 小时清除 93%）中快速、完全清除。 4 小时时没有器官保留> 0.7% 的放射性。对于球囊导管中放疗溶液 100% 损失（装置故障），除膀胱壁（2800 mGy，280 rad）、子宫（130 mGy，13 rad）和远端结肠（270 mGy，27 rad）外，所有器官将接收低于 100 mGy（10 rad）的辐射。正常情况下，所有器官剂量均低 1000 倍（< 3 mGy 或 0.3 rad）。
结论
在常规临床条件下，对正常器官的辐射剂量无关紧要。如果 Iotrex 的最大临床负荷（125I 的 16.7 GBq）在脑内释放，则所有器官的辐射剂量将低于确定性效应的阈值。
UNLABELLED
Iotrex is an aqueous radiotherapy solution containing sodium 3-(125I)iodo-4-hydroxybenzenesulfonate (125I-HBS), which is used as the radiation source for the brachytherapy of resected of brain tumor cavity margins with the GliaSite catheter. During routine clinical use of this brachytherapy applicator and radiation source, approximately 0.1% of the afterloaded Iotrex will diffuse through the GliaSite balloon. Our purpose was to assess the radiation doses to normal organs under routine clinical use of the GliaSite.
METHODS
Five groups of rats received intracerebral injections of an 131I-HBS solution (131I used as a surrogate for 125I in the synthesis of 125I-HBS) with one group sacrificed at 15 minutes, 30 minutes, 1 hour, 2 hours and 4 hours post-administration. Urine was collected and activity retention in numerous organs was measured. The biodistribution data were used to estimate radiation doses to normal organs of the Reference Adult Male and Female phantoms.
RESULTS
Radioactivity was rapidly and completely cleared from the brain (98% cleared by 2 hours) and total body (urinary clearance; 93%@2 hours). No organ retained > 0.7% of the radioactivity at 4 hours. For 100% loss of the radiotherapy solution from the balloon catheter (device failure), all organs would receive less than 100 mGy (10 rad), except the bladder wall (2800 mGy, 280 rad), uterus (130 mGy, 13 rad) and distal colon (270 mGy, 27 rad). Under normal conditions, all organ doses are 1000-fold lower (< 3 mGy or 0.3 rad).
CONCLUSIONS
Under routine clinical conditions, the radiation doses to normal organs are inconsequential. Should the maximum clinical load of Iotrex (16.7 GBq of 125I) be released intracerebrally, the radiation doses to all organs would be below the thresholds for deterministic effects.
实验药物诱导的肾功能变化和 99mTc-MDP 的生物分布。
影响因子：
6.7
作者：
McAfee,JG;Singh,A;Roskopf,M;Ritter,C;Lyons,B;Schoonmaker,JE;Thomas,FD;Jones,D
通讯作者：
Jones,D
证明近距离放射治疗可增强多形性胶质母细胞瘤的剂量-反应关系。
DOI：
10.1016/s0360-3016(96)85009-7
发表时间：
1996
期刊：
International journal of radiation oncology, biology, physics
影响因子：
--
作者：
Sneed,PK;Lamborn,KR;Larson,DA;Prados,MD;Malec,MK;McDermott,MW;Weaver,KA;Phillips,TL;Wara,WM;Gutin,PH
通讯作者：
Gutin,PH