From genomics to chemical genomics: new developments in KEGG.
From genomics to chemical genomics: new developments in KEGG.
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DOI：
10.1093/nar/gkj102
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发表时间：
2006-01-01
影响因子：
14.9
通讯作者：
Hirakawa M
中科院分区：
文献类型：
--
作者：
Kanehisa M;Goto S;Hattori M;Aoki-Kinoshita KF;Itoh M;Kawashima S;Katayama T;Araki M;Hirakawa M
越来越多的基因组和分子信息是理解更高级生物系统（如细胞和生物体）及其与环境的相互作用以及医学、工业和其他实际应用的基础。KEGG资源（）提供了一个将基因组与生物系统联系起来的参考知识库，分类为基因组空间（KEGG GENES）和化学空间（KEGG LIGAND）中的构建块，以及相互作用网络和反应网络的接线图（KEGG PATHWAY）。第四个组件KEGG BRITE已正式添加到KEGG数据库套件中。这反映了我们试图将计算机功能解释作为基于关于基因组、化学和网络空间的分层结构知识的途径重建过程的一部分。根据新的化学基因组学倡议，KEGG LIGAND的范围已显着扩大，涵盖内源性和外源性分子。具体而言，RPAIR包含从已知酶促反应中提取的策划化学结构转化模式，这将使基因组-环境相互作用的分析成为可能，例如预测新反应和降解新环境化合物的新酶基因。此外，药物信息现在单独存储，并链接到新的KEGG药物结构图。
The increasing amount of genomic and molecular information is the basis for understanding higher-order biological systems, such as the cell and the organism, and their interactions with the environment, as well as for medical, industrial and other practical applications. The KEGG resource () provides a reference knowledge base for linking genomes to biological systems, categorized as building blocks in the genomic space (KEGG GENES) and the chemical space (KEGG LIGAND), and wiring diagrams of interaction networks and reaction networks (KEGG PATHWAY). A fourth component, KEGG BRITE, has been formally added to the KEGG suite of databases. This reflects our attempt to computerize functional interpretations as part of the pathway reconstruction process based on the hierarchically structured knowledge about the genomic, chemical and network spaces. In accordance with the new chemical genomics initiatives, the scope of KEGG LIGAND has been significantly expanded to cover both endogenous and exogenous molecules. Specifically, RPAIR contains curated chemical structure transformation patterns extracted from known enzymatic reactions, which would enable analysis of genome-environment interactions, such as the prediction of new reactions and new enzyme genes that would degrade new environmental compounds. Additionally, drug information is now stored separately and linked to new KEGG DRUG structure maps.
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影响因子：
14.9
作者：
Tatusov, RL;Natale, DA;Koonin, EV
通讯作者：
Koonin, EV
影响因子：
14.9
作者：
Pruitt KD;Tatusova T;Maglott DR
通讯作者：
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影响因子：
15
作者：
Hattori, M;Okuno, Y;Kanehisa, M
通讯作者：
Kanehisa, M
影响因子：
11.4
作者：
Kanehisa, M
通讯作者：
Kanehisa, M
影响因子：
14.9
作者：
Kanehisa, M;Goto, S;Hattori, M
通讯作者：
Hattori, M