Photomodulation of DNA-Templated Supramolecular Assemblies.
Photomodulation of DNA-Templated Supramolecular Assemblies.
复制标题
DNA 模板超分子组装体的光调制。
作者：
Jenifer Rubio;T. Phan;Mathieu Fossépré;Valérie Matot;J. Knoops;T. Jarrosson;P. Dumy;F. Serein;C. Niebel;S. Ulrich;M. Surin
报道了一种新型的DNA配体，它含有一个磷酸盐结合基团和一个光敏偶氮苯部分。当偶氮苯处于反式构型时，配体与双链DNA的小沟结合，而在用光进行反式-顺式异构化时其部分解吸。光开关的配体与DNA的相互作用后的能力是证明（chir）的光学签名，并破译的结合几何形状，稳定性和动力学的DNA/配体复合物的两种异构体的差异。我们利用这些性质，通过掺入另一个π堆积DNA配体，与光响应配体一起形成混合的超分子复合物沿着DNA的光调制DNA模板的自组装。我们的研究表明，精心设计的光响应DNA粘合剂可用于调节多组分超分子DNA组装体。
A new type of DNA ligand that contains a phosphate-binding group and a photoresponsive azobenzene moiety is reported. When the azobenzene is in trans configuration, the ligand binds to the minor groove of a double-stranded DNA, whereas it partially desorbs upon trans-cis isomerisation with light. The ability to photoswitch the ligand upon interaction with DNA is evidenced by (chir)optical signatures, and deciphered by the differences of binding geometry, stability, and dynamics of the DNA/ligand complexes for the two isomers. We exploit these properties to photomodulate DNA-templated self-assembly, through the incorporation of another π-stacking DNA ligand, which together with the photoresponsive ligand form mixed supramolecular complexes along DNA. Our study demonstrates that well-designed photoresponsive DNA binders can be used to modulate multicomponent supramolecular DNA assemblies.
影响因子：
4.3
作者：
Brglez, Josipa;Nikolov, Pavel;Niemeyer, Christof M.
通讯作者：
Niemeyer, Christof M.