An exploratory human study of superstable homogeneous lipiodol-indocyanine green formulation for precise surgical navigation in liver cancer.
An exploratory human study of superstable homogeneous lipiodol-indocyanine green formulation for precise surgical navigation in liver cancer.
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DOI：
10.1002/btm2.10404
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发表时间：
2023-03
影响因子：
7.4
通讯作者：
Liu, Gang
中科院分区：
文献类型：
--
作者：
He, Pan;Xiong, Yongfu;Luo, Bin;Liu, Jianming;Zhang, Yang;Xiong, Yu;Su, Song;Fang, Cheng;Peng, Yisheng;Cheng, Hongwei;Chu, Chengchao;Mao, Jingsong;Li, Jingdong;Li, Bo;Yin, Zhenyu;Tian, Jie;Liu, Gang
经导管动脉栓塞（TAE）转化治疗联合肝切除术的临床应用因肿瘤边界不清和微小的隐藏病灶而受到严重限制。荧光手术导航是克服这些障碍的一种有前途的方法。然而，由于肿瘤供应动脉的阻塞，长期 TAE 后将荧光探针充分递送到肿瘤区域具有挑战性。这里，提供了一种超稳定均质混合配制技术（SHIFT），用于物理混合碘油和吲哚菁绿（ICG）制剂（SHIFT和ICG），用于长期TAE转换治疗后的荧光手术导航。通过对45例临床肝癌患者的回顾性研究，发现SHIFT和ICG制剂具有优异的肿瘤沉积效果和安全性。在长期 TAE 转换治疗后的手术切除过程中，SHIFT 和 ICG 可以清晰地实时识别完整的肿瘤区域和边界，并且具有较高的信号与正常组织比，即使是难以区分的卫星病灶也可以通过强荧光强度来识别。同时，SHIFT 和 ICG 可以改善与术后并发症相关的手术、麻醉和术后变量。这种简单有效的 SHIFT 可以为临床实践中长期栓塞治疗后的手术切除提供精确的荧光导航，并且具有巨大的转化管道潜力。
The clinical applications of transcatheter arterial embolization (TAE) conversion therapy combined with hepatectomy have been severely restricted by ill‐defined tumoral boundaries and miniscule hidden lesions. Fluorescent surgical navigation is a promising method for overcoming these barriers. However, sufficient delivery of the fluorescent probe into the tumor region after long‐term TAE is challenging due to blockade of the tumor‐supplying artery. Here, a super‐stable homogeneous intermix formulating technology (SHIFT) to physically mix lipiodol and indocyanine green (ICG) formulation (SHIFT and ICG) for fluorescent surgical navigation after long‐term TAE conversion therapy is provided. Through the retrospective study of 45 clinical liver cancer patients, it is found that SHIFT and ICG formulation have excellent tumor deposition effect and safety. During surgical resection after long‐term TAE conversion therapy, SHIFT and ICG could clearly identify in real time the full tumor regions and boundaries and had a high signal‐to‐normal tissues ratio—even the indistinguishable satellite lesions could be identified with a strong fluorescence intensity. Meanwhile, SHIFT and ICG could improve operative, anesthetic, and postoperative variables associated with postoperative complications. This simple and effective SHIFT could provide precise fluorescent navigation for surgical resection following long‐term embolization therapy in clinical practice and has great potential for a translational pipeline.
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影响因子：
3.8
作者：
Okumura, Shinya;Goumard, Claire;Scatton, Olivier
通讯作者：
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