Ocular toxicity of mustard gas: A concise review.
Ocular toxicity of mustard gas: A concise review.
复制标题
芥子气的眼毒性：简明综述。
DOI：
10.1016/j.toxlet.2021.02.007
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发表时间：
2021-06-01
影响因子：
3.5
通讯作者：
Mohan, Rajiv R.
中科院分区：
文献类型：
--
作者：
Fuchs, Allison;Giuliano, Elizabeth A.;Sinha, Nishant R.;Mohan, Rajiv R.
硫芥 (SM) 是一种化学战剂，在近代历史中一直被使用，至今仍然是一种威胁。暴露在空气中的士兵和平民会出现多种症状，主要出现在呼吸系统、皮肤和眼睛。眼组织对 SM 造成的损伤高度敏感，并会出现急性、慢性和迟发性并发症的独特表现，这些并发症在接触后可能持续数月甚至数年。这种独特的芥子气角膜病的机制尚未完全了解，并且讨论了用于研究这种疾病的动物模型。本综述包括损伤机制的最新进展。据报道，SM损伤的眼部表现包括持续性上皮缺陷、角膜缘干细胞缺乏、角膜新生血管、干眼和角膜混浊。人们已经研究了多种药物和手术疗法，并与潜在的未来疗法一起在此进行了回顾。
Sulfur mustard (SM) is a chemical warfare agent that has been used throughout recent history and remains a threat today. Exposed soldiers and civilians experience a variety of symptoms primarily in the respiratory system, skin, and eyes. The ocular tissues are highly sensitive to damage by SM and undergo unique manifestations of acute, chronic, and delayed complications that can persist for months and years after exposure. The mechanisms of this unique mustard gas keratopathy are still not fully understood and animal models for the study of this disease are discussed. Recent advances in mechanisms of injury are included in this review. Ophthalmic manifestations of SM injury including persistent epithelial defects, limbal stem cell deficiency, corneal neovascularization, dry eye, and corneal opacification have been reported. A wide variety of medical and surgical therapies have been studied and are reviewed here along with potential future therapies.
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