Variation in human brains may facilitate evolutionary change toward a limited range of phenotypes.
Variation in human brains may facilitate evolutionary change toward a limited range of phenotypes.
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DOI：
10.1159/000345940
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Finlay BL
中科院分区：
文献类型：
--
作者：
Charvet CJ;Darlington RB;Finlay BL
个体变异是进化的基础，但人们对大脑之间正常变异的性质知之甚少。哺乳动物大脑的系统发育变异的特征在于脑区体积的高度相关性、每个脑区的不同异速生长比例以及嗅觉和边缘结构体积与大脑其余部分的相对独立性。先前研究某些驯化物种个体的大脑变异的工作表明，系统发育变异的这三个特征反映在个体变异中。我们将这种分析扩展到人类大脑及其10个细分领域（例如，等皮质，海马体）的磁共振成像扫描的90人的大脑，年龄在16至25岁之间。人类大脑的变异与其他物种的个体变异和哺乳动物物种间的变异相似。也就是说，在人类和哺乳动物之间，每个脑区的斜率与髓质大小相比的相对差异是一致的，边缘系统结构的尺度与其他脑区的相对独立性有关。这种非随机的变异模式表明，发育程序引导了可供选择的变异。
Individual variation is the foundation for evolutionary change, but little is known about the nature of normal variation between brains. Phylogenetic variation across mammalian brains is characterized by high inter-correlations in brain region volumes, distinct allometric scaling for each brain region and the relative independence in olfactory and limbic structures volumes from the rest of the brain. Previous work examining brain variation in individuals of some domesticated species showed that these three features of phylogenetic variation were mirrored in individual variation. We extend this analysis to the human brain and 10 of its subdivisions (e.g., isocortex, hippocampus) by using magnetic resonance imaging scans of 90 human brains ranging between 16 to 25 years of age. Human brain variation resembles both the individual variation seen in other species, and variation observed across mammalian species. That is, the relative differences in the slopes of each brain region compared to medulla size within humans and between mammals are concordant, and limbic structures scale with relative independence from other brain regions. This non-random pattern of variation suggests that developmental programs channel the variation available for selection.
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影响因子：
3.3
作者：
Draghi, Jeremy;Wagner, Guenter R.
通讯作者：
Wagner, Guenter R.
影响因子：
3
作者：
Clancy, Barbara;Kersh, Brandon;Finlay, Barbara L.
通讯作者：
Finlay, Barbara L.
DOI：
10.1098/rspb.2010.0811
发表时间：
2010-11-22
影响因子：
4.7
作者：
Charvet, Christine J.;Striedter, Georg F.
通讯作者：
Striedter, Georg F.
影响因子：
1.7
作者：
Finlay, BL;Hersman, MN;Darlington, RB
通讯作者：
Darlington, RB
影响因子：
56.9
作者：
FINLAY, BL;DARLINGTON, RB
通讯作者：
DARLINGTON, RB