Leptin and insulin act on POMC neurons to promote the browning of white fat.
Leptin and insulin act on POMC neurons to promote the browning of white fat.
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DOI：
10.1016/j.cell.2014.12.022
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发表时间：
2015-01-15
期刊：
影响因子：
64.5
通讯作者：
Tiganis T
中科院分区：
文献类型：
--
作者：
Dodd GT;Decherf S;Loh K;Simonds SE;Wiede F;Balland E;Merry TL;Münzberg H;Zhang ZY;Kahn BB;Neel BG;Bence KK;Andrews ZB;Cowley MA;Tiganis T
白色脂肪组织（WAT）的主要任务是储存脂质。然而，“米色”脂肪细胞也存在于WAT中。米色脂肪细胞燃烧脂肪并以热量的形式耗散能量，但它们的丰度在肥胖症中减少。刺激米色脂肪细胞发育，或WAT布朗宁，增加能量消耗，并具有对抗代谢疾病和肥胖的潜力。在这里，我们报告胰岛素和瘦素共同作用于下丘脑神经元，促进WAT布朗宁和体重减轻。磷酸酶PTP1B和TCPTP的缺失增强了阿黑皮素原神经元中的胰岛素和瘦素信号传导，并通过增加WAT布朗宁和能量消耗来防止饮食诱导的肥胖。将胰岛素和瘦素共同输注到CNS或激活阿黑皮素原神经元也增加WAT布朗宁并减少肥胖。我们的研究结果确定了一个自我平衡的机制，协调状态的能量储存，胰岛素和瘦素中继，与中央控制的WAT布朗宁。
The primary task of white adipose tissue (WAT) is the storage of lipids. However, ‘beige’ adipocytes also exist in WAT. Beige adipocytes burn fat and dissipate the energy as heat, but their abundance is diminished in obesity. Stimulating beige adipocyte development, or WAT browning, increases energy expenditure and holds potential for combating metabolic disease and obesity. Here we report that insulin and leptin act together on hypothalamic neurons to promote WAT browning and weight loss. Deletion of the phosphatases PTP1B and TCPTP enhanced insulin and leptin signaling in proopiomelanocortin neurons and prevented diet-induced obesity by increasing WAT browning and energy expenditure. The co-infusion of insulin plus leptin into the CNS or the activation of proopiomelanocortin neurons also increased WAT browning and decreased adiposity. Our findings identify a homeostatic mechanism for coordinating the status of energy stores, as relayed by insulin and leptin, with the central control of WAT browning.
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影响因子：
16.2
作者：
Elias, CF;Aschkenasi, C;Elmquist, JK
通讯作者：
Elmquist, JK
影响因子：
15.9
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Banno, Ryoichi;Zimmer, Derek;Bence, Kendra K.
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作者：
Krashes, Michael J.;Koda, Shuichi;Lowell, Bradford B.
通讯作者：
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