The diagnostic value of zinc transporter 8 autoantibody (ZnT8A) for type 1 diabetes in Chinese.
The diagnostic value of zinc transporter 8 autoantibody (ZnT8A) for type 1 diabetes in Chinese.
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DOI：
10.1002/dmrr.1128
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发表时间：
2010-10
影响因子：
8
通讯作者：
Zhou, Zhiguang
中科院分区：
文献类型：
--
作者：
Yang, Lin;Luo, Shuoming;Huang, Gan;Peng, Jian;Li, Xia;Yan, Xiang;Lin, Jian;Wenzlau, Janet M.;Davidson, Howard W.;Hutton, John C.;Zhou, Zhiguang
Zinc transporter-8 (ZnT8) was recently identified as a novel autoantigen in human type 1 diabetes (T1D). Autoantibody to ZnT8 (ZnT8A) were detected in up to 80% of new-onset T1D and 26% of T1D patients otherwise classified as negative on the basis of existing markers. Since no data of ZnT8A in Chinese has been reported, we aim to evaluate the utility of ZnT8A for diagnosis of autoimmune T1D in Chinese relative to other autoantibody markers. Radioligand binding assays were performed on 539 T1D sera using human ZnT8 carboxyterminal 325Arg construct or a dimer incorporating 325Arg and 325Trp alongside antibodies to glutamic acid decarboxylase (GADA) or insulinoma-associated protein 2 (IA-2A). The antigenic specificity was analyzed in the context of clinical characteristics of the patients. ZnT8A were present in 24.1% (130/539) of T1D patients versus 1.8% (10/555) (P<0.001) in type 2 diabetes. At diagnosis, ZnT8A and IA-2A were less prevalent in Chinese T1D subjects than in Caucasian populations (both P<0.001), but similar to Japanese. The diagnostic sensitivity of combined GADA, IA-2A and ZnT8A measurements reached 65.5% with ZnT8A detected in 13.5% (29/215) of GADA and/or IA-2A negative subjects. ZnT8A prevalence was lower in older and fatter patients. ZnT8A+ alone patients were distinguished from Ab- ones (P<0.05~0.001) on the basis of higher insulin requirement and lower systolic blood pressure level. ZnT8A is an independent marker for T1D in Chinese and combined with GADA and IA-2A enhances diagnostic sensitivity. ZnT8A may be associated with different clinical phenotypes than GADA or IA-2A.
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DOI：
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