Computational studies on strain transmission from a collagen gel construct to a cell and its internal cytoskeletal filaments
Computational studies on strain transmission from a collagen gel construct to a cell and its internal cytoskeletal filaments
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从胶原凝胶结构到细胞及其内部细胞骨架丝的应变传递的计算研究
DOI：
10.1016/j.compbiomed.2014.10.015
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发表时间：
2014
影响因子：
7.7
通讯作者：
Shigeo Wada
中科院分区：
文献类型：
--
作者：
Yoshihiro Ujihara;Masanori Nakamura;Masatsugu Soga;Kenichiro Koshiyama;Hiroshi Miyazaki;Shigeo Wada
我们开发了一个机械组织模型，其中包含一个内部有细胞骨架细丝的细胞，以研究组织变形是如何反映在细胞及其内部细胞骨架细丝的变形中的。假设胶原凝胶结构的组织被描述为各向同性的线弹性材料，细胞被建模为包括细胞膜、核膜和细胞骨架细丝在内的离散元素的集合。根据最小能量原理计算了材料的力学行为。结果表明，组织变形的类型对细胞骨架细丝的变形有影响。当组织被拉伸时，细胞骨架细丝的应变分布偏向压缩，当组织被压缩时，细胞骨架细丝的应变偏向拉伸，而当组织被剪切时，细胞骨架细丝的应变分布几乎是正常的。这些结果还解决了细胞和细胞骨架细丝的变形与组织的杨氏模数与细胞的杨氏模数之比的关系。在组织拉伸时，细胞应变增加，细胞骨架细丝的应变分布在拉伸和压缩侧均变宽，杨氏模数比增大。这表明细胞骨架细丝应变的分布规律反映了组织的变形方式和组织/细胞的杨氏模数比。本模型对于理解组织中细胞反应的机制具有重要价值。
We developed a mechanical tissue model containing a cell with cytoskeletal filaments inside to investigate how tissue deformation is reflected in the deformation of a cell and its internal cytoskeletal filaments. Tissue that assumes a collagen gel construct was depicted as an isotropic linear elastic material, and the cell was modeled as an assembly of discrete elements including a cell membrane, nuclear envelope, and cytoskeletal filaments. Mechanical behaviors were calculated based on the minimum energy principle. The results demonstrated the effects of the type of tissue deformation on deformations of cytoskeletal filaments. The distribution of strains of cytoskeletal filaments was skewed toward compression when a tissue was stretched, toward stretch when the tissue was compressed, and almost normal when the tissue was sheared. The results also addressed the dependency of deformations of a cell and cytoskeletal filaments on the ratio of the Young’s modulus of a tissue to that of a cell. Upon tissue stretching, cell strain increased and the distribution of strains of cytoskeletal filaments broadened on both stretch and compression sides with an increase in the Young’s modulus ratio. This suggested that the manner of tissue deformation and the tissue/cell Young’s modulus ratio are reflected in the distribution pattern of strains of cytoskeletal filaments. The present model is valuable to understanding the mechanisms of cellular responses in a tissue.
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影响因子：
3.2
作者：
W. Grellmann
通讯作者：
W. Grellmann
定量计算诱导成骨细胞中细胞骨架肌动蛋白纤维结构重组的阈值纤维应变
DOI：
--
发表时间：
2005
期刊：
Journal of Biomechanics Vol. 38 No. 9
影响因子：
--
作者：
Taiji;Adachi;Katsuya;Sato
通讯作者：
Sato
影响因子：
--
作者：
Costa, KD;Hucker, WJ;Yin, FCP
通讯作者：
Yin, FCP
影响因子：
9.7
作者：
Gauvin, Robert;Parenteau-Bareil, Remi;Germain, Lucie
通讯作者：
Germain, Lucie
影响因子：
--
作者：
Carver W;Goldsmith EC
通讯作者：
Goldsmith EC