Variation in early-life telomere dynamics in a long-lived bird: links to environmental conditions and survival
Variation in early-life telomere dynamics in a long-lived bird: links to environmental conditions and survival
复制标题
长寿鸟类早期端粒动态的变化：与环境条件和生存的联系
DOI：
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发表时间：
2015
影响因子：
2.8
通讯作者：
P. Monaghan
中科院分区：
文献类型：
--
作者：
H. Watson;M. Bolton;P. Monaghan
早年经历的抽象状况可能会对短期和长期健康产生深远的影响。出生环境的变化已被证明影响整个野生脊椎动物种群的生存和繁殖性能。端粒动力学潜在地提供了早期环境和长期健康结果之间的联系，然而我们对环境如何影响早期生命的端粒动力学知之甚少。我们发现，生长过程中的环境条件对欧洲风暴海燕的早期生活端粒长度(TL)和雏鸟的磨损有重要影响。在不利的环境条件下饲养的雏鸟在出生后的发育过程中经历了显著的端粒丢失，而在较有利的出生条件下饲养的雏鸟的端粒丢失显著高于在较有利的环境条件下饲养的雏鸟，其TL的变化可以忽略不计。然而，在队列之间，未成熟的TL没有显著差异。结果表明，早期生活端粒动态可能有助于在不同环境条件下饲养的队列之间出现显著的生活史特征差异。早期生命的TL也被发现是雏鸟阶段存活的重要预测因子，为TL的变异和个体健康之间的联系提供了进一步的证据。早期生命TL和雏鸟阶段死亡率之间的关系在多大程度上是遗传、亲本和环境因素的结果目前尚不清楚，但这是一个有趣的未来研究领域。在这项研究中观察到，在不利条件下加速的端粒磨损，可能在调节早期生活环境对晚年表现的影响中发挥作用。摘要：环境强烈影响早期端粒磨损，这表明端粒动力学可能是自然人群中经常观察到的队列效应的基础，并可能机械地将早期应激与后期表现联系起来。
ABSTRACT Conditions experienced during early life can have profound consequences for both short- and long-term fitness. Variation in the natal environment has been shown to influence survival and reproductive performance of entire cohorts in wild vertebrate populations. Telomere dynamics potentially provide a link between the early environment and long-term fitness outcomes, yet we know little about how the environment can influence telomere dynamics in early life. We found that environmental conditions during growth have an important influence on early-life telomere length (TL) and attrition in nestlings of a long-lived bird, the European storm petrel Hydrobates pelagicus. Nestlings reared under unfavourable environmental conditions experienced significantly greater telomere loss during postnatal development compared with nestlings reared under more favourable natal conditions, which displayed a negligible change in TL. There was, however, no significant difference in pre-fledging TL between cohorts. The results suggest that early-life telomere dynamics could contribute to the marked differences in life-history traits that can arise among cohorts reared under different environmental conditions. Early-life TL was also found to be a significant predictor of survival during the nestling phase, providing further evidence for a link between variation in TL and individual fitness. To what extent the relationship between early-life TL and mortality during the nestling phase is a consequence of genetic, parental and environmental factors is currently unknown, but it is an interesting area for future research. Accelerated telomere attrition under unfavourable conditions, as observed in this study, might play a role in mediating the effects of the early-life environment on later-life performance. Summary: The environment strongly influences early-life telomere attrition, suggesting that telomere dynamics may underlie cohort effects often observed in natural populations and may mechanistically link early-life stress and later-life performance.
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DOI：
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发表时间：
2015-10
期刊：
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影响因子：
--
作者：
Douglas M. Bates;M. Maechler;Ben Bolker;Steven C. Walker
通讯作者：
Douglas M. Bates;M. Maechler;Ben Bolker;Steven C. Walker
儿童端粒快速缩短。
影响因子：
20.3
作者：
Zeichner,SL;Palumbo,P;Feng,Y;Xiao,X;Gee,D;Sleasman,J;Goodenow,M;Biggar,R;Dimitrov,D
通讯作者：
Dimitrov,D
影响因子：
14.9
作者：
Cawthon, RM
通讯作者：
Cawthon, RM
DOI：
10.1073/pnas.1113306109
发表时间：
2012-01-31
影响因子：
11.1
作者：
Heidinger, Britt J.;Blount, Jonathan D.;Monaghan, Pat
通讯作者：
Monaghan, Pat