Excitability and Threshold Mechanism for Enhanced Neuronal Response Induced by Inhibition Preceding Excitation.
Excitability and Threshold Mechanism for Enhanced Neuronal Response Induced by Inhibition Preceding Excitation.
复制标题
兴奋性和兴奋前抑制诱导的增强神经元反应的阈值机制
DOI：
10.1155/2021/6692411
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发表时间：
2021
影响因子：
3.1
通讯作者：
Gu H
中科院分区：
文献类型：
--
作者：
Ma H;Jia B;Li Y;Gu H
神经放电的抑制后易化（Postinhibitory facilitation，PIF）是一个矛盾的现象，即抑制效应导致放电活动的增强而不是减少，这在听觉神经系统的声音定位中起着重要作用，有待理论解释。在本文中，激发性和阈值机制的PIF现象的莫里斯-Lecar模型与I，II，III型激发性。首先，与施加到稳态的纯兴奋性刺激相比，当每对内的抑制性刺激和兴奋性刺激之间的间隔合适时，抑制性前兴奋性刺激形成对诱导II型和III型兴奋性而不是I型兴奋性的放电速率增加。其次，获得了PIF现象的阈值机制。对于II型和III型兴奋性，抑制性刺激诱导稳态附近的阈下振荡。在阈下振荡周期内的上升部分的中间和结束阶段以及下降部分的开始阶段期间，通过兴奋性刺激诱发动作电位的阈值变弱，这是PIF现象的原因。最后，对PIF现象的抑制性和兴奋性刺激之间的间隔范围进行了理论估计，在较强的刺激下，该间隔约为阈下振荡固有周期的一半，而在较弱的刺激下，该间隔变窄。由于阈下振荡的周期较短，III型激发性的PIF现象的间隔较短，更接近实验观察。结果给出了PIF现象的兴奋性和阈值机制，为PIF现象提供了全面而深入的解释。
Postinhibitory facilitation (PIF) of neural firing presents a paradoxical phenomenon that the inhibitory effect induces enhancement instead of reduction of the firing activity, which plays important roles in sound location of the auditory nervous system, awaited theoretical explanations. In the present paper, excitability and threshold mechanism for the PIF phenomenon is presented in the Morris-Lecar model with type I, II, and III excitabilities. Firstly, compared with the purely excitatory stimulations applied to the steady state, the inhibitory preceding excitatory stimulation to form pairs induces the firing rate increased for type II and III excitabilities instead of type I excitability, when the interval between the inhibitory and excitatory stimulation within each pair is suitable. Secondly, the threshold mechanism for the PIF phenomenon is acquired. For type II and III excitabilities, the inhibitory stimulation induces subthreshold oscillations around the steady state. During the middle and ending phase of the ascending part and the beginning phase of the descending part within a period of the subthreshold oscillations, the threshold to evoke an action potential by an excitatory stimulation becomes weaker, which is the cause for the PIF phenomenon. Last, a theoretical estimation for the range of the interval between the inhibitory and excitatory stimulation for the PIF phenomenon is acquired, which approximates half of the intrinsic period of the subthreshold oscillations for the relatively strong stimulations and becomes narrower for the relatively weak stimulations. The interval for the PIF phenomenon is much shorter for type III excitability, which is closer to the experiment observation, due to the shorter period of the subthreshold oscillations. The results present the excitability and threshold mechanism for the PIF phenomenon, which provide comprehensive and deep explanations to the PIF phenomenon.
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影响因子：
2.9
作者：
Ermentrout, B
通讯作者：
Ermentrout, B
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