Altered hippocampal functional connectivity after the rupture of anterior communicating artery aneurysm.
Altered hippocampal functional connectivity after the rupture of anterior communicating artery aneurysm.
复制标题
前交通动脉瘤破裂后海马功能连接发生改变
DOI：
10.3389/fnagi.2022.997231
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发表时间：
2022
影响因子：
4.8
通讯作者：
中科院分区：
文献类型：
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作者：
背景和目的动脉瘤性蛛网膜下腔出血（SAH）易导致海马损伤，这是后续认知功能障碍的主要原因。我们先前的研究揭示了前交通动脉瘤破裂后患者的静息态脑网络异常。然而，海马的功能连接（FC）特征及其与认知能力的关系，在这些患者仍然未知。方法本研究最终包括26例患者和19名年龄和性别匹配的对照者，他们完成了静息态功能磁共振成像（fMRI）的质量控制。从个体中提取海马体每一侧的平均时间序列，然后进行种子到体素分析。我们比较了两组之间的FC强度的差异，并随后分析了异常FC与他们的认知性能之间的相关性。结果基于双侧双侧颈动脉的FC分析结果基本一致。与健康对照组相比，ACoA动脉瘤破裂后患者表现出海马与Papez回路内其他脑结构之间的FC显著降低，包括双侧前扣带回和中扣带回（MCC），双侧内侧上级回和左侧颞下回（ITG）。相反，观察到海马和双侧海马之间的FC增加。相关性分析表明，更多的主观记忆投诉或较低的总认知评分与海马和几个大脑区域（如左前扣带皮层（ACC）和额颞叶皮层）的连通性降低有关。结论前交通动脉瘤破裂患者存在Papez环路内海马与多个脑区的低连通性。Papez回路失活可能是前交通动脉瘤破裂后患者认知功能障碍的重要神经机制。
Background and purpose Aneurysmal subarachnoid hemorrhage (SAH) predisposes hippocampal injury, a major cause of follow-up cognitive impairment. Our previous study has revealed an abnormal resting-state brain network in patients after the rupture of anterior communicating artery (ACoA) aneurysm. However, the functional connectivity (FC) characteristics of the hippocampus and its relationship with cognitive performance in these patients remain unknown. Methods This study ultimately included 26 patients and 19 age- and sex-matched controls who completed quality control for resting-state functional magnetic resonance imaging (fMRI). The mean time series for each side of the hippocampus was extracted from individuals and then a seed-to-voxel analysis was performed. We compared the difference in FC strength between the two groups and subsequently analyzed the correlations between abnormal FC and their cognitive performance. Results The results of bilateral hippocampus-based FC analysis were largely consistent. Compared with the healthy controls, patients after the rupture of ACoA aneurysm exhibited significantly decreased FC between the hippocampus and other brain structures within the Papez circuit, including bilateral anterior and middle cingulate cortex (MCC), bilateral medial superior frontal gyrus, and left inferior temporal gyrus (ITG). Instead, increased FC between the hippocampus and bilateral insula was observed. Correlation analyses showed that more subjective memory complaints or lower total cognitive scores were associated with decreased connectivity in the hippocampus and several brain regions such as left anterior cingulate cortex (ACC) and frontotemporal cortex. Conclusion These results extend our previous findings and suggest that patients with ruptured ACoA aneurysm exist hypoconnectivity between the hippocampus and multiple brain regions within the Papez circuit. Deactivation of the Papez circuit may be a crucial neural mechanism related to cognitive deficits in patients after the rupture of ACoA aneurysm.
影响因子：
2.7
作者：
Khursheed F;Rohlffs F;Suzuki S;Kim DH;Ellmore TM
通讯作者：
Ellmore TM