Artifact quantification and tractography from 3T MRI after placement of aneurysm clips in subarachnoid hemorrhage patients.
Artifact quantification and tractography from 3T MRI after placement of aneurysm clips in subarachnoid hemorrhage patients.
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DOI：
10.1186/1471-2342-11-19
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发表时间：
2011-10-04
影响因子：
2.7
通讯作者：
Ellmore TM
中科院分区：
文献类型：
--
作者：
Khursheed F;Rohlffs F;Suzuki S;Kim DH;Ellmore TM
应用先进的3 T MRI成像技术研究蛛网膜下腔出血（SAH）后的恢复情况，由于植入动脉瘤夹产生的图像伪影的存在而变得复杂。为了表征这些伪影对图像质量的影响，我们试图：1）在通常用于容量测定、血氧水平依赖性信号变化（BOLD-fMRI）和弥散加权成像（DW-MRI）研究的一系列MR序列中，量化植入动脉瘤夹的SAH患者的图像伪影程度; 2）探索重建这些患者的白色通路的能力。在3 T条件下，对2名分别在ACOM和左侧ACA植入钛合金夹的患者进行T1和T2加权结构、BOLD-fMRI和DW-MRI扫描。在对齐的图像体积上进行基于强度的平面轮廓绘制，以定义每个伪影。通过伪影/片段长度和伪影/脑体积比量化脑体积，并通过双因素（扫描-评分）ANOVA进行分析。使用确定性方法，在距离伪影不同距离处，从DW-MRI重建纤维束成像路径。MR序列的长度（p = 0.007）和体积（p < 0.001）比的MRI体积变化：结构图像的体积最小，DW-MRI采集的体积较大，fMRI图像的体积最大。评价者间可靠性较高（r = 0.9626，p < 0.0001），并且白色物质连接性特征的重建随着距伪影边界的距离而增加。在这两名患者中，钩束和额枕下束的重建白色物质通路在伪影边界的2 mm内清晰可见。先进的3 T MR可以根据序列类型在不同的空间范围内成功地对植入钛动脉瘤夹周围的脑组织进行成像。可以重建和可视化剪辑伪影附近的白色物质路径。这些发现为设计aSAH患者放置夹后恢复的功能和结构神经影像学研究提供了参考。
The application of advanced 3T MRI imaging techniques to study recovery after subarachnoid hemorrhage (SAH) is complicated by the presence of image artifacts produced by implanted aneurysm clips. To characterize the effect of these artifacts on image quality, we sought to: 1) quantify extent of image artifact in SAH patients with implanted aneurysm clips across a range of MR sequences typically used in studies of volumetry, blood oxygen level dependent signal change (BOLD-fMRI), and diffusion-weighted imaging (DW-MRI) and 2) to explore the ability to reconstruct white matter pathways in these patients. T1- and T2-weighted structural, BOLD-fMRI, and DW-MRI scans were acquired at 3T in two patients with titanium alloy clips in ACOM and left ACA respectively. Intensity-based planimetric contouring was performed on aligned image volumes to define each artifact. Artifact volumes were quantified by artifact/clip length and artifact/brain volume ratios and analyzed by two-way (scan-by-rater) ANOVAs. Tractography pathways were reconstructed from DW-MRI at varying distances from the artifacts using deterministic methods. Artifact volume varied by MR sequence for length (p = 0.007) and volume (p < 0.001) ratios: it was smallest for structural images, larger for DW-MRI acquisitions, and largest on fMRI images. Inter-rater reliability was high (r = 0.9626, p < 0.0001), and reconstruction of white matter connectivity characteristics increased with distance from the artifact border. In both patients, reconstructed white matter pathways of the uncinate fasciculus and inferior fronto-occipital fasciculus were clearly visible within 2 mm of the artifact border. Advanced 3T MR can successfully image brain tissue around implanted titanium aneurysm clips at different spatial ranges depending on sequence type. White matter pathways near clip artifacts can be reconstructed and visualized. These findings provide a reference for designing functional and structural neuroimaging studies of recovery in aSAH patients after clip placement.
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