Gut microbiota, determined by dietary nutrients, drive modification of the plasma lipid profile and insulin resistance.
Gut microbiota, determined by dietary nutrients, drive modification of the plasma lipid profile and insulin resistance.
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由膳食营养素决定的肠道微生物群驱动血脂谱和胰岛素抵抗的改变。
DOI：
10.1016/j.isci.2021.102445
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发表时间：
2021-05-21
期刊：
影响因子：
5.8
通讯作者：
Tobe K
中科院分区：
文献类型：
--
作者：
Watanabe Y;Fujisaka S;Ikeda K;Ishikawa M;Yamada T;Nawaz A;Kado T;Kuwano T;Nishimura A;Bilal M;Liu J;Yagi K;Hase K;Tobe K
肠道菌群代谢营养物质，产生各种代谢物，在宿主代谢中起着至关重要的作用。然而，由不同营养物质建立的微生物群与微生物群影响的血浆脂质的变化之间的联系尚不清楚。富含玉米淀粉、果糖、支链氨基酸、大豆油或猪油的日粮建立了独特的微生物群，并对葡萄糖代谢产生了影响，部分影响是通过微生物群的转移来复制的。无菌小鼠和定植小鼠的血浆脂质组学分析比较显示，微生物群对各种脂质类别有显著影响，值得注意的是，由SO饮食建立的微生物群与最大程度的葡萄糖耐受不良相关，导致血浆脂质谱的最大改变。因此，由膳食营养素组成的肠道微生物群与血脂的动态变化有关，可能对葡萄糖代谢产生不同的影响。不同营养成分对糖代谢的影响差异饲粮富豆油（SO）饲粮建立的肠道微生物群对糖代谢的影响存在动态影响；微生物;Lipidomics
The gut microbiota metabolizes the nutrients to produce various metabolites that play crucial roles in host metabolism. However, the links between the microbiota established by different nutrients and the microbiota-influenced changes in the plasma lipids remain unclear. Diets rich in cornstarch, fructose, branched chain amino acids, soybean oil (SO), or lard established a unique microbiota and had influence on glucose metabolism, which was partially reproduced by transferring the microbiota. Comparison of plasma lipidomic analysis between germ-free and colonized mice revealed significant impacts of the microbiota on various lipid classes, and of note, the microbiota established by the SO diet, which was associated with the greatest degree of glucose intolerance, caused the maximum alteration of the plasma lipid profile. Thus, the gut microbiota composed of dietary nutrients was associated with dynamic changes in the lipids potentially having differential effects on glucose metabolism. Diets with different nutrient compositions differentially affect glucose metabolism Gut microbiota established by soybean oil-rich (SO) diet impairs glucose metabolism Gut microbiota established by diets has dynamic effects on the plasma lipid profile SO diet has the greatest impact on the plasma lipid profile through gut microbiota Microbiology ; Microbiome ; Lipidomics
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