Androgen receptor expresion in breast cancer: relationship with clinicopathological characteristics of the tumors, prognosis, and expression of metalloproteases and their inhibitors.
Androgen receptor expresion in breast cancer: relationship with clinicopathological characteristics of the tumors, prognosis, and expression of metalloproteases and their inhibitors.
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DOI：
10.1186/1471-2407-8-149
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发表时间：
2008-05-28
期刊：
影响因子：
3.8
通讯作者：
Vizoso FJ
中科院分区：
文献类型：
--
作者：
Gonzalez LO;Corte MD;Vazquez J;Junquera S;Sanchez R;Alvarez AC;Rodriguez JC;Lamelas ML;Vizoso FJ
在本研究中，我们分析了乳腺癌患者中雄激素受体（AR）的肿瘤表达及其与临床病理特征、几种基质金属蛋白酶（MMPs）及其抑制剂（TIMPs）的表达以及与预后的关系。免疫组织化学研究使用组织微阵列和针对AR、MMPs -1、-2、-7、-9、-11、-13、-14和TIMPs -1、-2和-3的特异性抗体进行。对111例原发性浸润性乳腺导管癌患者（52例伴有腋窝淋巴结转移，59例无腋窝淋巴结转移）和对照组的肿瘤标本进行了2800多项检测。染色结果使用基于染色强度的评分进行分类，特定的软件程序自动计算免疫染色细胞的百分比。83例（74.8%）AR免疫染色阳性，但染色分值差异较大。AR的总免疫染色评分与任何临床病理参数之间没有显著相关性。然而，ar阳性肿瘤的MMP-1、-7和-13评分值明显高于ar阴性肿瘤。同样，当我们考虑表达每种因子的细胞类型时，我们发现ar阳性肿瘤的恶性细胞中MMP-1、-7、-11和TIMP-2以及瘤内成纤维细胞中MMP-1阳性的病例比例更高。另一方面，多变量分析显示ar阳性肿瘤患者的总生存期明显长于ar阴性乳腺癌患者（p = 0.03）。我们的研究结果证实了AR在乳腺癌中普遍表达，并且与一些MMPs和TIMP-2的表达相关。虽然我们发现AR表达的特定值是乳腺癌的预后指标，但AR在这些肿瘤中的功能作用尚不清楚，需要进一步的数据来阐明其在乳腺癌中的生物学意义。
In the present study we analyze, in patients with breast cancer, the tumor expression of androgen receptors (AR), its relationship with clinicopathological characteristics and with the expression of several matrix metalloproteases (MMPs) and their inhibitors (TIMPs), as well as with prognosis. An immunohistochemical study was performed using tissue microarrays and specific antibodies against AR, MMPs -1, -2, -7, -9, -11, -13, -14, and TIMPs -1, -2 and -3. More than 2,800 determinations on tumor specimens from 111 patients with primary invasive ductal carcinoma of the breast (52 with axillary lymph node metastases and 59 without them) and controls were performed. Staining results were categorized using a score based on the intensity of the staining and a specific software program calculated the percentage of immunostained cells automatically. A total of 83 cases (74.8%) showed a positive immunostaining for AR, but with a wide variation in the staining score values. There were no significant associations between the total immunostaining scores for AR and any clinicopathological parameters. However, score values for MMP-1, -7 and -13, were significantly higher in AR-positive tumors than in AR-negative tumors. Likewise, when we considered the cellular type expressing each factor, we found that AR-positive tumors had a higher percentage of cases positive for MMP-1, -7, -11, and TIMP-2 in their malignant cells, as well as for MMP-1 in intratumoral fibroblasts. On the other hand, multivariate analysis demonstrated that patients with AR-positive tumors have a significant longer overall survival than those with AR-negative breast carcinomas (p = 0.03). Our results confirm that AR are commonly expressed in breast cancer, and are correlated with the expression of some MMPs and TIMP-2. Although we found a specific value of AR expression to be a prognostic indicator in breast cancer, the functional role of AR in these neoplasms is still unclear and further data are needed in order to clarify their biological signification in breast cancer.
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人类乳腺癌中雄激素受体和雄激素响应蛋白载脂蛋白D的表达。
影响因子：
8.8
作者：
Hall, R E;Aspinall, J O;Horsfall, D J;Birrell, S N;Bentel, J M;Sutherland, R L;Tilley, W D
通讯作者：
Tilley, W D
影响因子：
2.8
作者：
Gatalica, Z
通讯作者：
Gatalica, Z
影响因子：
4.8
作者：
Mañes, S;Llorente, M;Martínez-A, C
通讯作者：
Martínez-A, C
影响因子：
4.8
作者：
Fingleton, B;Vargo-Gogola, T;Matrisian, LM
通讯作者：
Matrisian, LM
影响因子：
8.8
作者：
Gonzalez, L. O.;Pidal, I.;Junquera, S.;Corte, M. D.;Vazquez, J.;Rodriguez, J. C.;Lamelas, M. L.;Merino, A. M.;Garcia-Muniz, J. L.;Vizoso, F. J.
通讯作者：
Vizoso, F. J.