Genome-wide analysis of cancer cell-derived Foxp3 target genes in human tongue squamous cell carcinoma cells.
Genome-wide analysis of cancer cell-derived Foxp3 target genes in human tongue squamous cell carcinoma cells.
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人舌鳞状细胞癌细胞中癌细胞来源的 Foxp3 靶基因的全基因组分析
DOI：
10.3892/ijo.2015.2926
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发表时间：
2015-05
影响因子：
5.2
通讯作者：
Liao GQ
中科院分区：
文献类型：
--
作者：
Liang YJ;Lao XM;Liang LZ;Liao GQ
The forkhead transcription factor Foxp3 is essential for differentiation and activation of regulatory T cells (Tregs), and used to be regarded as specific transcription factor of Tregs. In recent years, Foxp3 expression in tumor cells (cancer cell-derived Foxp3) has gained great interest, but its function and molecular mechanisms remain incompletely understood. In the present study, we detected dynamic nuclear translocation of Foxp3 in TSCC cells using immunofluorescent staining. Then we performed a genome-wide analysis of Foxp3 in TSCC cells using a combination of ChIP-on-chip and whole-genome microarray assays. We also compared Foxp3 biding sites in TSCC cells with the known binding sites in human Tregs to show the differences in transcriptional regulation profile. Results indicate that Foxp3 in TSCC cells has distinct biological functions compared with that in Tregs. Cancer cell-derived Foxp3 directly regulates the transcription of genes that affect certain internal biological processes of TSCC cells, and indirectly influences the extracellular microenvironment. This study reveals the relationship between direct and indirect targets genes of Foxp3 in TSCC cells and provide molecular basis of cancer cell-derived Foxp3 function.
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影响因子：
3.8
作者：
Ladoire, Sylvain;Arnould, Laurent;Ghiringhelli, Francois
通讯作者：
Ghiringhelli, Francois
影响因子：
64.8
作者：
Marson, Alexander;Kretschmer, Karsten;Young, Richard A.
通讯作者：
Young, Richard A.
体细胞单次攻击可使前列腺中的 X 连锁肿瘤抑制因子 FOXP3 失活。
影响因子：
50.3
作者：
Wang, Lizhong;Liu, Runhua;Li, Weiquan;Chen, Chong;Katoh, Hiroto;Chen, Guo-Yun;McNally, Beth;Lin, Lin;Zhou, Penghui;Zuo, Tao;Cooney, Kathleen A.;Liu, Yang;Zheng, Pan
通讯作者：
Zheng, Pan
DOI：
10.1073/pnas.0700298104
发表时间：
2007-03-13
影响因子：
11.1
作者：
Li, Bin;Samanta, Arabinda;Greene, Mark I.
通讯作者：
Greene, Mark I.
影响因子：
64.5
作者：
Wu, Yongqing;Borde, Madhuri;Rao, Anjana
通讯作者：
Rao, Anjana