Adenoviral Gene Therapy for Pancreatic Cancer: Where Do We Stand?
Adenoviral Gene Therapy for Pancreatic Cancer: Where Do We Stand?
复制标题
胰腺癌的腺病毒基因治疗：我们的立场如何？
作者：
K. Kuhlmann;D. Gouma;J. Wesseling
背景：胰腺癌患者预后较差。这主要是由于诊断晚，侵袭性生物学和缺乏有效的治疗方式。腺病毒基因疗法具有选择性治疗原发性肿瘤和（微）转移组织的潜力。方法：本文综述了迄今为止在腺病毒基因治疗胰腺癌领域取得的进展。结果：转导靶向可以降低载体传播到非靶细胞的毒性，并允许以较低的病毒剂量递送。它可以逃避或减少免疫反应，这仍然是一个主要问题。转录靶向发展迅速，但本质上的缺点，如缺乏有效的动物模型延迟临床应用。目前，利用腺病毒在胰腺癌患者中进行的临床试验很少。在世界范围内，只有7项III期试验正在进行，研究腺病毒载体在癌症患者中的作用。结论：腺病毒基因治疗胰腺癌的疗效尚未明确，因为从实验台到床边的步骤遇到了缺陷。结合不同的靶向策略和技术来逃避免疫系统，为胰腺癌患者的腺病毒基因治疗提供了未来。
Background: The prognosis of patients with pancreatic cancer is poor. This is mainly caused by the late diagnosis, the aggressive biology and the lack of effective treatment modalities. Adenoviral gene therapy has the potential to selectively treat both primary tumor and (micro)metastatic tissue. Methods: This review provides an overview of what has been achieved so far in the field of adenoviral gene therapy for pancreatic cancer. Results: Transductional targeting allows decreased toxicity due to vector dissemination to non-target cells and permits delivery with a lower viral dose. It can evade or diminish the immune response, which remains a major problem. Transcriptional targeting evolves quickly but essential drawbacks such as the lack of an efficient animal model delay clinical application. Few clinical trials utilizing adenoviruses have been performed in patients with pancreatic cancer today. Worldwide, only seven phase III trials are being performed investigating adenoviral vectors in cancer patients. Conclusion: A clear therapeutic effect of adenoviral gene therapy in pancreatic cancer has not yet been achieved, because the step from bench to bedside has encountered drawbacks. Combinations of the different targeting strategies and techniques to evade the immune system harbor the future for adenoviral gene therapy in patients with pancreatic cancer.
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ONYX-015 的体内抗肿瘤活性受到 p53 状态的影响，并通过放射治疗增强。
DOI：
--
发表时间：
2000
期刊：
Cancer research.
影响因子：
--
作者：
Rogulski,KR;Freytag,SO;Zhang,K;Gilbert,JD;Paielli,DL;Kim,JH;Heise,CC;Kirn,DH
通讯作者：
Kirn,DH
影响因子：
56.9
作者：
Bewley, MC;Springer, K;Flanagan, JM
通讯作者：
Flanagan, JM
影响因子：
3.7
作者：
Short, JJ;Pereboev, AV;Curiel, DT
通讯作者：
Curiel, DT
影响因子：
8.4
作者：
Kim, M;Zinn, KR;Douglas, JT
通讯作者：
Douglas, JT
影响因子：
6
作者：
Iacobuzio-Donahue, CA;Maitra, A;Goggins, M
通讯作者：
Goggins, M