Mass spectrometry of structurally modified DNA.

Mass spectrometry of structurally modified DNA.
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DOI:
10.1021/cr300391r
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发表时间:
2013-04-10
期刊:
影响因子:
62.1
通讯作者:
Kotapati, Srikanth
Kotapati, Srikanth
中科院分区:
化学1区
文献类型:
--
作者:
Tretyakova, Natalia;Villalta, Peter W.;Kotapati, Srikanth

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Structural modifications of nucleobases within the deoxyribonucleic acid (DNA) of living cells can be induced as a result of actions of specialized DNA-modifying enzymes (creating epigenetic DNA modifications) or may result from exposure to reactive endogenous and exogenous electrophiles and oxidants (creating DNA adducts). Epigenetic DNA modifications such as 5-methylcytosine (MeC) are important regulators of cell function that influence chromatin structure and control the levels of gene expression. DNA methyltransferases (DMTs) catalyze the addition of the C-5 methyl group to cytosine
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