Local Immunodeficiency: Combining Cross-Immunoreactivity Networks
Local Immunodeficiency: Combining Cross-Immunoreactivity Networks
复制标题
局部免疫缺陷：结合交叉免疫反应网络
DOI：
10.1089/cmb.2022.0390
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发表时间：
2023
影响因子：
1.7
通讯作者：
Ram, Athulya
中科院分区：
文献类型：
--
作者：
Bunimovich, Leonid;Ram, Athulya
本文继续分析最近观察到的局部免疫缺陷（LI）的现象，这是由于组织成网络的交叉免疫反应性（CR）的宿主内病毒之间的抗原合作。我们在这里研究了组合（连接）最简单的CR网络的结果会发生什么，这些网络具有稳定的LI状态。事实证明，有许多可能性，特别是导致CR网络中某些病毒的角色发生变化。我们的结果也给出了一些迹象表明，在所有可能的CR网络的整个集合中，具有LI稳定状态的CR网络的集合的边界。这种边界CR网络的特征在于LI的仅边缘稳定（中性而不是稳定）状态，或者在CR网络中存在彼此独立地演化的这种子网（尽管是连接的）。
This article continues the analysis of the recently observed phenomenon of local immunodeficiency (LI), which arises as a result of antigenic cooperation among intrahost viruses organized into a network of cross-immunoreactivity (CR). We study here what happens as the result of combining (connecting) the simplest CR networks, which have a stable state of LI. It turned out that many possibilities occur, particularly resulting in a change of roles of some viruses in the CR network. Our results also give some indications about a boundary of the set of CR networks with stable state of LI in the entire collection of all possible CR networks. Such borderline CR networks are characterized by only a marginally stable (neutral rather than stable) state of the LI, or by the existence of such subnetworks in a CR network that evolve independently of each other (although being connected).
影响因子：
5.4
作者：
FREITAS, AA;ROSADO, MM;GRANDIEN, A
通讯作者：
GRANDIEN, A
影响因子：
3.7
作者：
Ines Gismondi, Maria;Diaz Carrasco, Juan Maria;Victoria Preciado, Maria
通讯作者：
Victoria Preciado, Maria