Day-night variation of acute myocardial infarction in obstructive sleep apnea.
Day-night variation of acute myocardial infarction in obstructive sleep apnea.
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DOI：
10.1016/j.jacc.2008.04.027
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发表时间：
2008-07-29
影响因子：
24
通讯作者：
Somers, Virend K.
中科院分区：
文献类型：
--
作者：
Sert Kuniyoshi, Fatima H.;Garcia-Touchard, Arturo;Gami, Apoor S.;Romero-Corral, Abel;van der Walt, Christelle;Pusalavidyasagar, Snigdha;Kara, Tomas;Caples, Sean M.;Pressman, Gregg S.;Vasquez, Elisardo C.;Lopez-Jimenez, Francisco;Somers, Virend K.
To evaluate the day-night variation of acute myocardial infarction (MI) in patients with obstructive sleep apnea (OSA). OSA has a high prevalence and is characterized by acute nocturnal hemodynamic and neurohormonal abnormalities that may increase the risk of MI during the night. We prospectively studied 92 patients with MI, for which the time of onset of chest pain was clearly identified. The presence of OSA was determined by overnight polysomnography. For patients with and without OSA we compared the frequency of MI during different intervals of the day based on the onset time of chest pain. The groups had similar prevalence of comorbidities. MI occurred between midnight and 6am in 32% of OSA patients and 7% of non-OSA patients (P=0.01). The odds of having OSA in those patients whose MI occurred between midnight and 6am was six-fold higher than in the remaining 18 hours of the day (95% C.I: 1.3 −27.3, P=0.01). Of all patients having an MI between midnight and 6am, 91% had OSA. The diurnal variation in the onset of MI in OSA patients is strikingly different from the diurnal variation in non-OSA patients. Patients with nocturnal onset of MI have a high likelihood of having OSA. These findings suggest that OSA may be a trigger for MI. Patients having nocturnal onset of MI should be evaluated for OSA, and future research should address the effects of OSA therapy for prevention of nocturnal cardiac events. We studied 92 patients with MI, for whom the time of onset of chest pain was clearly identified. MI occurred between midnight and 6am in 32% of OSA patients and 7% of non-OSA patients (P=0.01). The odds of having OSA in those patients whose MI occurred between midnight and 6am was 6 fold higher than in the remaining 18 hours of the day (95% C.I: 1.3 −27.3, P=0.01). The diurnal variation in the onset of MI in patients with OSA is strikingly different; patients with nocturnal onset of MI have a high likelihood of having OSA.
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影响因子：
15.9
作者：
SOMERS, VK;DYKEN, ME;ABBOUD, FM
通讯作者：
ABBOUD, FM
影响因子：
9.6
作者：
Mooe, T;Rabben, T;Eriksson, P
通讯作者：
Eriksson, P
影响因子：
158.5
作者：
MULLER, JE;STONE, PH;BRAUNWALD, E
通讯作者：
BRAUNWALD, E
DOI：
10.1164/ajrccm.153.6.8665063
发表时间：
1996-06-01
影响因子：
24.7
作者：
Chin, K;Ohi, M;Kuno, K
通讯作者：
Kuno, K
影响因子：
158.5
作者：
Gami, AS;Howard, DE;Somers, VK
通讯作者：
Somers, VK