Mutually constructive roles of Ail and LPS in Yersinia pestis serum survival
Mutually constructive roles of Ail and LPS in Yersinia pestis serum survival
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Ail 和 LPS 在鼠疫耶尔森氏菌血清存活中的相互建设性作用
DOI：
10.1111/mmi.14530
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发表时间：
2020
影响因子：
3.6
通讯作者：
Anisimov, Andrey P.
中科院分区：
文献类型：
--
作者：
Singh, Chandan;Lee, Hwayoung;Tian, Ye;Schesser Bartra, Sara;Hower, Suzanne;Fujimoto, Lynn M.;Yao, Yong;Ivanov, Sergey A.;Shaikhutdinova, Rima Z.;Anisimov, Andrey P.
The outer membrane is a key virulence determinant of gram‐negative bacteria. InYersinia pestis, the deadly agent that causes plague, the protein Ail and lipopolysaccharide (LPS)6enhance lethality by promoting resistance to human innate immunity and antibiotics, enabling bacteria to proliferate in the human host. Their functions are highly coordinated. Here we describe how they cooperate to promote pathogenesis. Using a multidisciplinary approach, we identify mutually constructive interactions between Ail and LPS that produce an extended conformation of Ail at the membrane surface, cause thickening and rigidification of the LPS membrane, and collectively promoteY. pestissurvival in human serum, antibiotic resistance, and cell envelope integrity. The results highlight the importance of the Ail–LPS assembly as an organized whole, rather than its individual components, and provide a handle for targetingY. pestispathogenesis.
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影响因子：
3.3
作者：
Klauda, Jeffery B.;Venable, Richard M.;Freites, J. Alfredo;O'Connor, Joseph W.;Tobias, Douglas J.;Mondragon-Ramirez, Carlos;Vorobyov, Igor;MacKerell, Alexander D., Jr.;Pastor, Richard W.
通讯作者：
Pastor, Richard W.
影响因子：
3.4
作者：
Balusek, Curtis;Gumbart, James C.
通讯作者：
Gumbart, James C.
影响因子：
3.4
作者：
E. Wu;O. Engström;Sunhwan Jo;Danielle Stuhlsatz;M. S. Yeom;Jeffery B. Klauda;G. Widmalm;W. Im
通讯作者：
E. Wu;O. Engström;Sunhwan Jo;Danielle Stuhlsatz;M. S. Yeom;Jeffery B. Klauda;G. Widmalm;W. Im
原核和真核蛋白质识别脂多糖的保守结构基序。
影响因子：
5.7
作者：
A. Ferguson;W. Welte;E. Hofmann;B. Lindner;O. Holst;J. Coulton;K. Diederichs
通讯作者：
K. Diederichs
影响因子：
2.9
作者：
Knirel, YA;Lindner, B;Anisimov, AP
通讯作者：
Anisimov, AP