Cast immobilization increases long-interval intracortical inhibition.
Cast immobilization increases long-interval intracortical inhibition.
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DOI：
10.1002/mus.21694
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发表时间：
2010-09
期刊：
影响因子：
3.4
通讯作者：
Thomas, James S.
中科院分区：
文献类型：
--
作者：
Clark, Brian C.;Taylor, Janet L.;Hoffman, Richard L.;Dearth, Douglas J.;Thomas, James S.
固定会降低肌肉的性能，尽管这些性能损失与神经损伤有关，但对于皮质特性的适应却知之甚少。我们利用经颅磁刺激来评估接受 3 周固定的健康人的桡侧腕屈肌 (FCR) 皮质内促进 (ICF) 以及短间隔和长间隔皮质内抑制 (SICI 和 LICI) 的变化。在休息和收缩期间（15% 强度）进行测量。还评估了中枢激活和霍夫曼反射（H 反射）。固定后力量下降 43.2% ± 6.1%，中枢激活也下降（97.5% ± 2.4% 至 73.2% ± 8.3%）。静息时未观察到 ICF、SICI 或 LICI 变化；然而，LICI 在收缩期间增加（无条件反应的 67.5% ± 6.9% 至 53.1% ± 6.7%）。 LANCI 的增加与力量损失相关（r = -0.63）。固定后 H 反射增强。这些发现表明，固定会增加收缩期间的皮质内抑制，并且这种增加主要由 GABAB 受体介导。
Immobilization reduces muscle performance, and despite these performance losses being associated with neural impairments little is known regarding adaptations in cortical properties. We utilized transcranial magnetic stimulation to assess changes in flexor carpi radialis (FCR) intracortical facilitation (ICF), and short- and long-interval intracortical inhibition (SICI and LICI) in healthy humans undergoing 3 weeks of immobilization. Measurements were obtained at rest and during contraction (15% intensity). Central activation and the Hoffman reflex (H-reflex) were also assessed. Strength decreased 43.2% ± 6.1% following immobilization, and central activation also decreased (97.5% ± 2.4% to 73.2% ± 8.3%). No changes in ICF, SICI, or LICI were observed at rest; however, LICI was increased during contraction (67.5% ± 6.9% to 53.1% ± 6.7% of unconditioned response). The increase in LICI correlated with the loss of strength (r = −0.63). The H-reflex increased following immobilization. These findings suggest that immobilization increases intracortical inhibition during contraction, and this increase is primarily mediated by GABAB receptors.
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影响因子：
3.3
作者：
Clark, Brian C.;Issac, Lailah C.;Hoffman, Richard L.
通讯作者：
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影响因子：
3.3
作者：
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影响因子：
2
作者：
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DOI：
10.1016/j.apmr.2008.06.032
发表时间：
2009-01-01
影响因子：
4.3
作者：
Clark, Brian C.;Manini, Todd M.;Russ, David W.
通讯作者：
Russ, David W.
影响因子：
3.3
作者：
Aagaard, P;Simonsen, EB;Dyhre-Poulsen, P
通讯作者：
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