Heritability of Parkinson disease in Swedish twins: a longitudinal study.
Heritability of Parkinson disease in Swedish twins: a longitudinal study.
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DOI：
10.1016/j.neurobiolaging.2011.02.017
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发表时间：
2011-10
影响因子：
4.2
通讯作者：
Pedersen NL
中科院分区：
文献类型：
--
作者：
Wirdefeldt K;Gatz M;Reynolds CA;Prescott CA;Pedersen NL
Previous twin studies report no heritability of Parkinson disease (PD) based on cross-sectional information. Here, we apply a longitudinal design and re-evaluate cross-sectional data in the population-based Swedish Twin Registry (STR) using clinical as well as hospital discharge and cause of death diagnoses. In the longitudinal analyses (based on 46,436 individuals), we identified 542 twins with PD and 65 twins with parkinsonism. Concordance rates for PD were 11% for monozygotic and 4% for same-sexed dizygotic twin pairs, with a heritability estimate of 34%. Concordance rates for PD or parkinsonism were 13% for monozygotic and 5% for same-sexed dizygotic twin pairs, with a heritability estimate of 40%. In the cross-sectional analyses (based on 49,814 individuals), we identified 287 twins with PD and 79 twins with parkinsonism. Concordance rates for PD were 4% for monozygotic and same-sexed dizygotic twin pairs and zero for opposite-sexed twin pairs. Concordance rates for PD or parkinsonism were somewhat higher but the heritability estimate was non-significant. Our longitudinal analyses demonstrate that PD and parkinsonism are modestly heritable.
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影响因子：
6.6
作者：
MCGUE, M
通讯作者：
MCGUE, M
影响因子：
30.8
作者：
Satake, Wataru;Nakabayashi, Yuko;Toda, Tatsushi
通讯作者：
Toda, Tatsushi
影响因子：
2.6
作者：
DEFRIES, JC;FULKER, DW
通讯作者：
FULKER, DW
DOI：
10.1056/nejmoa0901281
发表时间：
2009-10-22
期刊：
The New England journal of medicine
影响因子：
--
作者：
Sidransky E;Nalls MA;Aasly JO;Aharon-Peretz J;Annesi G;Barbosa ER;Bar-Shira A;Berg D;Bras J;Brice A;Chen CM;Clark LN;Condroyer C;De Marco EV;Dürr A;Eblan MJ;Fahn S;Farrer MJ;Fung HC;Gan-Or Z;Gasser T;Gershoni-Baruch R;Giladi N;Griffith A;Gurevich T;Januario C;Kropp P;Lang AE;Lee-Chen GJ;Lesage S;Marder K;Mata IF;Mirelman A;Mitsui J;Mizuta I;Nicoletti G;Oliveira C;Ottman R;Orr-Urtreger A;Pereira LV;Quattrone A;Rogaeva E;Rolfs A;Rosenbaum H;Rozenberg R;Samii A;Samaddar T;Schulte C;Sharma M;Singleton A;Spitz M;Tan EK;Tayebi N;Toda T;Troiano AR;Tsuji S;Wittstock M;Wolfsberg TG;Wu YR;Zabetian CP;Zhao Y;Ziegler SG
通讯作者：
Ziegler SG
DOI：
10.1375/1369052012506
发表时间：
2001-10-01
期刊：
Twin research : the official journal of the International Society for Twin Studies
影响因子：
--
作者：
Christensen, K;Wienke, A;Yashin, A I
通讯作者：
Yashin, A I