Upregulation of PODXL and ITGB1 in pancreatic cancer tissues preoperatively obtained by EUS-FNAB correlates with unfavorable prognosis of postoperative pancreatic cancer patients.
Upregulation of PODXL and ITGB1 in pancreatic cancer tissues preoperatively obtained by EUS-FNAB correlates with unfavorable prognosis of postoperative pancreatic cancer patients.
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DOI：
10.1371/journal.pone.0265172
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发表时间：
2022
期刊：
影响因子：
3.7
通讯作者：
Furihata M
中科院分区：
文献类型：
--
作者：
Taniuchi K;Ueno M;Yokose T;Sakaguchi M;Yoshioka R;Ogasawara M;Kosaki T;Naganuma S;Furihata M
PODXL和ITGB1在手术切除的胰腺癌组织中的表达上调与术后预后不良有关。本研究的目的是探讨PODXL和ITGB1是否是胰腺癌术后患者预后的有用的术前标志物，并与TNM分期系统进行比较。应用抗PODXL和抗ITGB1抗体对24例术前经内窥镜超声引导细针穿刺活检的胰腺癌组织标本进行免疫组织化学染色。COX比例风险回归分析UICC TNM分期、PODXL和ITGB1表达上调是否与术后总生存率相关。单因素分析显示PODXL、TNM分期、淋巴侵犯、PODXL与ITGB1联合应用与术后生存有关。多因素分析显示，TNM分期、PODXL和ITGB1联合应用与术后生存有关，其中PODXL和ITGB1联合应用对胰腺癌患者术后预后的预测更为准确。因此，PODXL和ITGB1的表达上调可作为胰腺癌患者术前新辅助治疗的指征，准确预测术后预后。
The upregulation of PODXL and ITGB1 in surgically resected pancreatic cancer tissues is correlated with an unfavorable postoperative prognosis. The aim of this study was to investigate whether PODXL and ITGB1 are useful preoperative markers for the prognosis of postoperative pancreatic cancer patients in comparison with the TNM staging system. Immunohistochemistry was performed using anti-PODXL and anti-ITGB1 antibodies on 24 pancreatic cancer tissue samples preoperatively obtained by endoscopic ultrasound-guided fine-needle aspiration biopsy. Cox proportional hazards regression analysis was performed to investigate if the UICC TNM stage and upregulation of PODXL and ITGB1 were correlated with postoperative overall survival rates. Univariate analysis revealed that PODXL, TNM stage, lymphatic invasion and the combination of PODXL with ITGB1 are correlated with postoperative survival. Multivariate analysis demonstrated TNM stage and the combination of PODXL with ITGB1 to be correlated with postoperative survival, and the combination of PODXL with ITGB1 most accurately predicted the postoperative outcomes of pancreatic cancer patients before resection. Therefore, upregulation of PODXL and ITGB1 may indicate preoperative neoadjuvant therapy for pancreatic cancer patients by accurately predicting the postoperative prognosis.
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影响因子：
4
作者：
Taniuchi K;Tsuboi M;Sakaguchi M;Saibara T
通讯作者：
Saibara T
影响因子：
5.7
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Bouvet, Michael
影响因子：
3.7
作者：
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Adsay, Volkan