High fat diet induces formation of spontaneous liposarcoma in mouse adipose tissue with overexpression of interleukin 22.
High fat diet induces formation of spontaneous liposarcoma in mouse adipose tissue with overexpression of interleukin 22.
复制标题
高脂肪饮食诱导小鼠脂肪组织中自发性脂肪肉瘤的形成并过度表达白细胞介素 22
DOI：
10.1371/journal.pone.0023737
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Chen Y
中科院分区：
文献类型：
--
作者：
Wang Z;Yang L;Jiang Y;Ling ZQ;Li Z;Cheng Y;Huang H;Wang L;Pan Y;Wang Z;Yan X;Chen Y
白细胞介素22（IL-22）是T细胞分泌的细胞因子，其调节非造血组织如上皮和肝脏中的炎症反应。IL-22在脂肪组织中的功能目前尚不清楚。我们建立了一个在脂肪组织中特异性过表达IL-22的转基因小鼠模型。IL-22转基因小鼠经高脂饲料喂养后，肥胖和胰岛素抵抗无明显变化。出乎意料的是，所有用HFD喂养4个月的IL-22转基因小鼠都在附睾脂肪组织中产生了自发性肿瘤。组织学分析表明，肿瘤为分化良好的脂肪肉瘤，伴有炎性细胞浸润。IL-22过表达促进炎性细胞因子如IL-1β和IL-10的产生，并刺激脂肪组织中的ERK磷酸化。此外，IL-22处理分化的3 T3-L1脂肪细胞可诱导IL-1β和IL-10表达，并刺激ERK磷酸化。综上所述，我们的研究不仅建立了一种新的自发性脂肪肉瘤小鼠模型，而且还揭示了IL-22过表达可能与饮食诱导的肥胖共同影响小鼠肿瘤的发展。
Interleukin 22 (IL-22) is a T-cell secreted cytokine that modulates inflammatory response in nonhematopoietic tissues such as epithelium and liver. The function of IL-22 in adipose tissue is currently unknown. We generated a transgenic mouse model with overexpression of IL-22 specifically in adipose tissue. The IL-22 transgenic mice had no apparent changes in obesity and insulin resistance after feeding with high fat diet (HFD). Unexpectedly, all the IL-22 transgenic mice fed with HFD for four months developed spontaneous tumors in epididymal adipose tissue. Histological analysis indicated that the tumors were well-differentiated liposarcomas with infiltration of inflammatory cells. IL-22 overexpression promotes production of inflammatory cytokines such as IL-1β and IL-10 and stimulates ERK phosphorylation in adipose tissue. Furthermore, IL-22 treatment in differentiated 3T3-L1 adipocytes could induce IL-1β and IL-10 expression, together with stimulation of ERK phosphorylation. Taken together, our study not only established a novel mouse model with spontaneous liposarcoma, but also revealed that IL-22 overexpression may collaborate with diet-induced obesity to impact on tumor development in mouse.
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影响因子：
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