The IQGAP scaffolds: Critical nodes bridging receptor activation to cellular signaling.
The IQGAP scaffolds: Critical nodes bridging receptor activation to cellular signaling.
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DOI：
10.1083/jcb.202205062
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发表时间：
2023-06-05
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影响因子：
--
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中科院分区：
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David Sacks and colleagues review the crosstalk between cell surface receptors and the IQGAP scaffold proteins. The scaffold protein IQGAP1 assembles multiprotein signaling complexes to influence biological functions. Cell surface receptors, particularly receptor tyrosine kinases and G-protein coupled receptors, are common IQGAP1 binding partners. Interactions with IQGAP1 modulate receptor expression, activation, and/or trafficking. Moreover, IQGAP1 couples extracellular stimuli to intracellular outcomes via scaffolding of signaling proteins downstream of activated receptors, including mitogen-activated protein kinases, constituents of the phosphatidylinositol 3-kinase pathway, small GTPases, and β-arrestins. Reciprocally, some receptors influence IQGAP1 expression, subcellular localization, binding properties, and post-translational modifications. Importantly, the receptor:IQGAP1 crosstalk has pathological implications ranging from diabetes and macular degeneration to carcinogenesis. Here, we describe the interactions of IQGAP1 with receptors, summarize how they modulate signaling, and discuss their contribution to pathology. We also address the emerging functions in receptor signaling of IQGAP2 and IQGAP3, the other human IQGAP proteins. Overall, this review emphasizes the fundamental roles of IQGAPs in coupling activated receptors to cellular homeostasis.
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影响因子：
4.8
作者：
Chen, CH;Zheng, B;Lin, SC
通讯作者：
Lin, SC
影响因子：
5.3
作者：
Balenci, Laurent;Saoudi, Yasmina;Baudier, Jacques
通讯作者：
Baudier, Jacques
影响因子：
5.6
作者：
Yuan Z;Zhang W;Tan W
通讯作者：
Tan W
DOI：
10.1073/pnas.1323106111
发表时间：
2014-04-01
影响因子：
11.1
作者：
Carmon, Kendra S.;Gong, Xing;Liu, Qingyun
通讯作者：
Liu, Qingyun
影响因子：
4.8
作者：
Bourguignon, LYW;Gilad, E;Peyrollier, K
通讯作者：
Peyrollier, K