Anterior cingulate cortical volumes and treatment remission of geriatric depression.
Anterior cingulate cortical volumes and treatment remission of geriatric depression.
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DOI：
10.1002/gps.2290
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发表时间：
2009-08
影响因子：
4
通讯作者：
Alexopoulos, George S.
中科院分区：
文献类型：
--
作者：
Gunning, Faith M.;Cheng, Janice;Murphy, Christopher F.;Kanellopoulos, Dora;Acuna, Jessica;Hoptman, Matthew J.;Klimstra, Sibel;Morimoto, Shizuko;Weinberg, James;Alexopoulos, George S.
前扣带皮层（ACC）的结构异常可能会干扰参与情绪调节的皮层和边缘系统网络的相互作用，并导致老年人的慢性抑郁综合征。本研究探讨了老年抑郁症患者的区域前扣带回皮质体积与治疗缓解的关系。我们假设在艾司西酞普兰12周对照治疗试验中未能缓解的患者比缓解的患者表现出更小的前扣带回灰质体积。参与者是41名患有非精神病性重度抑郁症的非痴呆个体。在2周的单盲安慰剂治疗期后，汉密尔顿抑郁量表（HDRS）评分仍为18分或更高的受试者接受艾司西酞普兰10 mg每日一次，持续12周。缓解定义为至少连续2周HDRS评分为7或更低。患者样本包括22名在研究期间获得缓解的抑郁症患者和19名仍有症状的抑郁症患者。在1.5特斯拉扫描仪上采集高分辨率MPPT序列，并手动勾画区域ACC体积（背侧、吻侧、膝下前部和膝下后部）。重复测量分析显示，艾司西酞普兰治疗后未能缓解的患者的背侧和头侧前扣带回灰质体积小于缓解的患者，而两组之间的膝下皮质体积没有差异。背侧和喙侧前扣带回的结构异常可能使晚年抑郁症永久化。
Structural abnormalities of the anterior cingulate cortex (ACC) may interfere with the interaction of cortical and limbic networks involved in emotional regulation and contribute to chronic depressive syndromes in the elderly. This study examined the relationship of regional anterior cingulate cortical volumes to treatment remission of elderly depressed patients. We hypothesized that patients who failed to remit during a 12-week controlled treatment trial of escitalopram would exhibit smaller anterior cingulate gray matter volumes than patients who remitted. The participants were 41 non-demented individuals with non-psychotic major depression. After a 2-week single blind placebo period, subjects who still had a Hamilton Depression Rating Scale (HDRS) of 18 or greater received escitalopram 10 mg daily for 12 weeks. Remission was defined as a HDRS score of 7 or below for at least 2 consecutive weeks. The patient sample consisted of 22 depressed patients who achieved remission during the study and 19 depressed patients who remained symptomatic. High-resolution MPRAGE sequences were acquired on a 1.5 Tesla scanner and regional ACC volumes were manually outlined (dorsal, rostral, anterior subgenual, and posterior subgenual). Repeated measures analyses revealed that patients who failed to remit following escitalopram treatment had smaller dorsal and rostral anterior cingulate gray matter volumes than patients who remitted, whereas subgenual cortical volumes did not differ between the groups. Structural abnormalities of the dorsal and rostral anterior cingulate may perpetuate late-life depression.
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影响因子：
7.2
作者：
Aizenstein, Howard J.;Butters, Meryl A.;Wu, Minjie;Mazurkewicz, Laura M.;Stenger, V. Andrew;Gianaros, Peter J.;Becker, James T.;Reynolds, Cbarles F., III;Carter, Cameron S.
通讯作者：
Carter, Cameron S.
影响因子：
17.7
作者：
Kennedy, Sidney H.;Konarski, Jakub Z.;Mayberg, Helen S.
通讯作者：
Mayberg, Helen S.
影响因子：
6.7
作者：
Holthoff, VA;Beuthien-Baumann, B;Herholz, K
通讯作者：
Herholz, K
影响因子：
17.7
作者：
Alexopoulos, George S.;Murphy, Christopher F.;Hoptman, Matthew J.
通讯作者：
Hoptman, Matthew J.
影响因子：
6.7
作者：
Mayberg, HS
通讯作者：
Mayberg, HS