NGL-2 regulates input-specific synapse development in CA1 pyramidal neurons.
NGL-2 regulates input-specific synapse development in CA1 pyramidal neurons.
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DOI：
10.1016/j.neuron.2012.10.013
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发表时间：
2012-11-21
期刊：
影响因子：
16.2
通讯作者：
Ghosh A
中科院分区：
文献类型：
--
作者：
DeNardo LA;de Wit J;Otto-Hitt S;Ghosh A
An important organizing feature of the CNS is that individual neurons receive input from many different sources. Independent regulation of synaptic input is critical for the function and adaptive responses of the nervous system, but the underlying molecular mechanisms are not well understood. We identify the leucine-rich repeat (LRR)-containing protein NGL-2 (Lrrc4) as a key regulator of input-specific synapse development in the hippocampus. Using genetic deletion and shRNA-mediated knockdown, we demonstrate a role for NGL-2 in regulating the strength of synaptic transmission and spine density specifically at Schaffer collateral synapses in the stratum radiatum (SR) in CA1. NGL-2 protein is restricted to SR and spine regulation requires NGL-2’s LRR and PDZ-binding domains. Finally, loss of NGL-2 disrupts cooperative interactions between distal and proximal synapses in CA1 pyramidal cells. These results demonstrate that NGL-2 is critical for pathway-specific synapse development and functional integration of distinct inputs.
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DOI：
10.1523/jneurosci.0470-10.2010
发表时间：
2010-06-02
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Siddiqui TJ;Pancaroglu R;Kang Y;Rooyakkers A;Craig AM
通讯作者：
Craig AM
影响因子：
16.2
作者：
Ko, Jaewon;Fuccillo, Marc V.;Malenka, Robert C.;Suedhof, Thomas C.
通讯作者：
Suedhof, Thomas C.
影响因子：
25
作者：
Kim, Seho;Burette, Alain;Kim, Eunjoon
通讯作者：
Kim, Eunjoon
影响因子：
56.9
作者：
Nakashiba, Toshiaki;Young, Jennie Z.;Tonegawa, Susumu
通讯作者：
Tonegawa, Susumu
影响因子：
64.8
作者：
Passafaro, M;Nakagawa, T;Sheng, M
通讯作者：
Sheng, M