Comparison of the roles of insulin and insulin-like growth factor I in casein gene expression and in the development of alpha-lactalbumin and glucose transport activities in the mouse mammary epithelial cell.
Comparison of the roles of insulin and insulin-like growth factor I in casein gene expression and in the development of alpha-lactalbumin and glucose transport activities in the mouse mammary epithelial cell.
复制标题
比较胰岛素和胰岛素样生长因子 I 在小鼠乳腺上皮细胞酪蛋白基因表达以及 α-乳清蛋白和葡萄糖转运活性发展中的作用。
DOI：
10.1210/endo-120-4-1411
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发表时间：
1987
期刊：
影响因子：
4.8
通讯作者：
Yale J. Topper
中科院分区：
文献类型：
--
作者：
C. Prosser;Lakshmanan Sankaran;Lothar Hennighausen;Yale J. Topper
比较了胰岛素和胰岛素样生长因子I(IGF-I；在氢化可的松和PRL存在下)在中期妊娠小鼠乳腺上皮细胞中积累的β-酪蛋白mRNA、总酪蛋白合成、α-乳清蛋白和基础载体介导的葡萄糖转运活性的浓度-活性曲线。对于酪蛋白mRNA的积累、酪蛋白合成和α-乳白蛋白活性的诱导，胰岛素ED50为1-2 ng/ml，而IGF-I的ED50为10-20倍。在这些情况下，胰岛素和IGF-I的作用不是相加的。对于基础载体介导的葡萄糖转运的诱导，胰岛素ED50为8 ng/ml，IGF-I为16 ng/ml，这两种因子都能诱导细胞转运活性达到2日龄哺乳小鼠细胞的水平。在这种情况下，这种影响是相加的；胰岛素和IGF-I一起可以诱导转运到10天的哺乳水平。
The concentration-activity profiles for insulin and insulin-like growth factor I (IGF-I; in the presence of and insulin-like growth factor I (IGF-I; in the presence of hydrocortisone and PRL) have been compared in terms of the accumulation of beta-casein mRNA, total casein synthesis, and alpha-lactalbumin and basal carrier-mediated glucose transport activities in mammary epithelial cells from midpregnant mice. For the accumulation of the casein mRNA and the induction of casein synthesis and alpha-lactalbumin activity, the insulin ED50 is 1-2 ng/ml, while that for IGF-I is 10- to 20-fold greater. The effects of insulin and IGF-I are not additive in these instances. For the induction of basal carrier-mediated glucose transport, the insulin ED50 is 8 ng/ml, and that for IGF-I is 16 ng/ml. Either factor can induce transport activity up to the level present in the cells from 2-day lactating mice. In this instance the effects are additive; insulin and IGF-I together can induce the transport up to the 10-day lactating level.
Somatomedin-C 通过培养的大鼠颗粒细胞中的卵泡刺激素增强黄体生成素受体的诱导。
影响因子：
4.8
作者：
Adashi,EY;Resnick,CE;Svoboda,ME;VanWyk,JJ
通讯作者：
VanWyk,JJ
胰岛素样生长因子（IGF I 和 IGF II）模拟胰岛素对培养肝细胞中血浆蛋白合成和糖原沉积的影响。
DOI：
10.1016/0006-291x(86)90581-4
发表时间：
1986
影响因子：
3.1
作者：
Parkes,JL;Cardell,RR;Grieninger,G
通讯作者：
Grieninger,G