Quantitative CT measurement of cross-sectional area of small pulmonary vessel in COPD: correlations with emphysema and airflow limitation.
Quantitative CT measurement of cross-sectional area of small pulmonary vessel in COPD: correlations with emphysema and airflow limitation.
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DOI：
10.1016/j.acra.2009.07.022
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发表时间：
2010-01
影响因子：
4.8
通讯作者：
Hatabu, Hiroto
中科院分区：
文献类型：
--
作者：
Matsuoka, Shin;Washko, George R.;Dransfield, Mark T.;Yamashiro, Tsuneo;Estepar, Raul San Jose;Diaz, Alejandro;Silverman, Edwin K.;Patz, Samuel;Hatabu, Hiroto
肺血管改变是COPD的特征性表现之一。最近的研究表明，血管改变与内皮功能障碍密切相关，并可能进一步受到肺气肿的影响。然而，肺小血管的形态学改变和肺气肿的程度之间的关系尚未在体内进行评估。本研究的目的是：1）使用CT扫描评估肺小血管的总横截面积（CSA）与肺气肿和气流阻塞程度的相关性，以及2）评估COPD表型之间总CSA的差异。我们测量了191名受试者的CSA小于5 mm 2和5-10 mm 2，并使用CT扫描计算了肺面积占总CSA的百分比（分别为%CSA<5和%CSA 5 -10）。计算肺气肿程度（%LAA-950），并评估%CSA<5和%CSA 5 -10与%LAA-950和肺功能试验（PFT）结果的相关性。还评估了COPD表型之间%CSA的差异。%CSA<5与%LAA-950呈显著负相关（r=-0.83，p<0.0001）。%CSA<5与FEV1%预测值（r=0.29，p<0.0001）和FEV 1/FVC（r=0.45，p<0.0001）之间存在微弱但具有统计学意义的相关性。% CSA 5 -10与%LAA-950和PFT结果相关性较弱。%CSA<5在支气管炎表型中显著高于肺气肿表型（p<0.0001）。肺小血管在亚亚段水平的总横截面积与肺气肿的程度（%LAA-950）密切相关，并反映了COPD表型之间的差异。
Pulmonary vascular alteration is one of the characteristic features of COPD. Recent studies suggest that vascular alteration is closely related to endothelial dysfunction, and may be further influenced by emphysema. However, the relationship between morphological alteration of small pulmonary vessels and the extent of emphysema has not been assessed in vivo. The objectives of this study are: 1) to evaluate the correlation of total cross-sectional area (CSA) of small pulmonary vessels with the extent of emphysema and airflow obstruction using CT scans, and 2) to assess the difference of total CSA between COPD phenotypes. We measured CSA less than 5mm2 and 5–10 mm2, and calculated the percentage of the total CSA for the lung area (%CSA<5, and %CSA5-10, respectively) using CT scans in 191 subjects. The extent of emphysema (%LAA-950) was calculated, and the correlations of %CSA<5 and %CSA5-10 with %LAA-950 and results of pulmonary function tests (PFTs) were evaluated. The differences in %CSA between COPD phenotypes were also assessed. %CSA<5 had significant negative correlations with %LAA-950 (r=−0.83, p<0.0001). There was a weak but statistically significant correlation of %CSA<5 with FEV1% predicted (r=0.29, p<0.0001) and FEV1/FVC (r=0.45, p<0.0001). %CSA5-10 had weak correlations with %LAA-950 and results of PFTs. %CSA<5 was significantly higher in bronchitis phenotype than emphysema phenotype (p<0.0001). Total cross sectional area of small pulmonary vessels at sub-subsegmental levels strongly correlates with the extent of emphysema (%LAA-950), and reflects differences between COPD phenotypes.
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DOI：
10.1164/ajrccm.149.2.8306040
发表时间：
1994-02-01
影响因子：
24.7
作者：
BARBERA, JA;RIVEROLA, A;RODRIGUEZROISIN, R
通讯作者：
RODRIGUEZROISIN, R
影响因子：
2.8
作者：
CORDASCO, EM;BEEREL, FR;TOFFOLO, RR
通讯作者：
TOFFOLO, RR
影响因子：
5
作者：
MUSK, AW
通讯作者：
MUSK, AW
DOI：
10.1177/003591576505800907
发表时间：
1965-01-01
期刊：
PROCEEDINGS OF THE ROYAL SOCIETY OF MEDICINE-LONDON
影响因子：
--
作者：
SCARROW, GD
通讯作者：
SCARROW, GD
影响因子：
9.6
作者：
Tan, RT;Kuzo, R;Presberg, KW
通讯作者：
Presberg, KW