Compromised gastrointestinal integrity in pigtail macaques is associated with increased microbial translocation, immune activation, and IL-17 production in the absence of SIV infection.
Compromised gastrointestinal integrity in pigtail macaques is associated with increased microbial translocation, immune activation, and IL-17 production in the absence of SIV infection.
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猪尾猕猴（PTM）在SIV感染后迅速发展为艾滋病。鉴于HIV/SIV疾病进展与微生物易位和免疫激活之间的强烈关联，我们评估了PTM中是否存在高基础水平的免疫激活和微生物易位。我们发现，在SIV感染之前，PTM有高水平的微生物易位，这与胃肠道结构屏障的严重损害相关。此外，这种增加的微生物易位与高水平的免疫激活相关，并与产生il -17的T细胞的高频率相关。这些数据强调了在没有HIV/SIV复制的情况下粘膜损伤、微生物易位和全身免疫激活之间的关系，并强调了微生物易位在SIV感染的PTM疾病快速进展过程中的重要性。此外，这些数据表明PTM可能是研究旨在减少微生物易位诱导的免疫激活的治疗干预的理想模型。
Pigtail macaques (PTM) rapidly progress to AIDS after SIV infection. Given the strong association between HIV/SIV disease progression and microbial translocation and immune activation, we assessed whether high basal levels of immune activation and microbial translocation exist in PTM. We found that prior to SIV infection, PTM had high levels of microbial translocation that correlated with significant damage to the structural barrier of the GI tract. Moreover, this increased microbial translocation correlated with high levels of immune activation and was associated with high frequencies of IL-17-producing T cells. These data highlight the relationship between mucosal damage, microbial translocation and systemic immune activation in the absence of HIV/SIV replication and underscore the importance of microbial translocation in the rapid course of disease progression in SIV-infected PTM. Furthermore, these data suggest that PTM may be an ideal model to study therapeutic interventions aimed at decreasing microbial translocation-induced immune activation.
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DOI：
10.1084/jem.20070663
发表时间：
2007-08-06
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Annunziato F;Cosmi L;Santarlasci V;Maggi L;Liotta F;Mazzinghi B;Parente E;Filì L;Ferri S;Frosali F;Giudici F;Romagnani P;Parronchi P;Tonelli F;Maggi E;Romagnani S
通讯作者：
Romagnani S
影响因子：
8.8
作者：
Baroncelli, Silvia;Galluzzo, Clementina Maria;Palmisano, Lucia
通讯作者：
Palmisano, Lucia
影响因子：
3.9
作者：
Haller, Otto;Staeheli, Peter;Kochs, Georg
通讯作者：
Kochs, Georg
影响因子：
8
作者：
Boirivant, M.;Amendola, A.;Butera, A.
通讯作者：
Butera, A.
影响因子：
4.8
作者：
Aggarwal, S;Ghilardi, N;Gurney, AL
通讯作者：
Gurney, AL