Swimming improves cognitive reserve in ovariectomized rats and enhances neuroprotection after global cerebral ischemia
Swimming improves cognitive reserve in ovariectomized rats and enhances neuroprotection after global cerebral ischemia
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游泳可改善卵巢切除大鼠的认知储备并增强全脑缺血后的神经保护
DOI：
10.1016/j.brainres.2018.05.020
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发表时间：
2018-08
期刊：
影响因子：
--
通讯作者：
Ruimin Wang
中科院分区：
文献类型：
--
作者：
Meng Zhang;Yating Zhai;Yaping Sun;Wenli Zhang;Qian Li;Brann DW;Ruimin Wang
认知储备已被提出来解释对脑损伤或病理的不同反应。影响认知储备的因素包括认知参与、身体活动、休闲活动、压力水平和饮食。此外，据报道，长期卵巢切除术（OVX），如发生在经历手术绝经的妇女中，会增加认知障碍的风险。在目前的研究中，我们研究了游泳是否能改善长期OVX大鼠的认知功能。我们还研究了全脑缺血（GCI）后游泳的神经保护作用，并探讨了游泳预处理对MAPK级联信号通路、突触蛋白和脑源性生长因子（BDNF）激活的影响--所有这些因素都与调节突触可塑性和脑神经保护有关。将成年SD大鼠随机分为4组：假手术组（Sham，Sh）、假手术+游泳组（Sham + Sw）、缺血再灌注组（IR，IR + Sw）。结果表明：（1）Morris水迷宫和穿梭箱实验结果显示，游泳可改善去卵巢大鼠的认知功能;（2）游泳可增加去卵巢大鼠海马内PSD 95和突触素的水平，以及p-ERK、p-CREB和BDNF的蛋白表达;（3）游泳可增加存活神经元的数量和IL 4的蛋白表达，同时降低海马中的Iba 1（小胶质细胞标记物）水平。总之，我们的研究表明游泳可以改善OVX大鼠的记忆力，游泳预处理可以增强神经保护性ERK 1/2/CREB/BDNF途径信号传导，改善OVX大鼠GCI后的脑损伤，这可能与诱导IL 4密切相关介导的抗炎机制。
Cognitive reserve has been proposed to account for different responses to brain damage or pathology. Factors implicated to influence cognitive reserve include cognitive engagement, physical activity, leisure activities, stress levels, and diet. Furthermore, long-term ovariectomy (OVX), such as occurs in women that have underwent surgical menopause, has been reported to increase the risk of cognitive impairment. In the current study, we examined whether swimming improves cognitive function in long-term OVX-rats. We also examined the neuroprotective effect of swimming after global cerebral ischemia (GCI) and explored the effect of swimming preconditioning on activation of the MAPK cascade signaling pathway, synaptic proteins and brain-derived growth factor (BDNF) – all factors implicated in regulating synaptic plasticity and neuroprotection in the brain. Adult Sprague–Dawley OVX-rats were randomly assigned into four groups: Sham (Sh), Sham + Swimming (Sh + Sw), Ischemia/Reperfusion (IR) and IR + Sw. Our results revealed that (1) Morris water maze and shuttle box test analysis revealed that swimming improved cognitive function in OVX-rats, (2) The levels of PSD95 and synaptophysin, as well as the protein expression of p-ERK, p-CREB and BDNF were all increased in the hippocampus after swimming with or without GCI, and (3) Swimming also increased the number of surviving neurons and IL4 protein expression, while decreasing the Iba1 (a microglia marker) level in the hippocampus. In conclusion, our study demonstrates that swimming improves memory in OVX-rats, and that swimming preconditioning enhances the neuroprotective ERK1/2/CREB/BDNF pathway signaling and ameliorates brain damage after GCI in OVX-rats, which may be closely related to induction of an IL4-mediated anti-inflammatory mechanism.
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DOI：
10.1016/j.jagp.2015.05.009
发表时间：
2015-11
期刊：
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
影响因子：
--
作者：
Wroolie TE;Kenna HA;Williams KE;Rasgon NL
通讯作者：
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DOI：
10.1097/00004647-200207000-00009
发表时间：
2002-07-01
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