Interleukin-17A Contributed to the Damage of Blood-CNS Barriers During Streptococcus suis Meningitis
Interleukin-17A Contributed to the Damage of Blood-CNS Barriers During Streptococcus suis Meningitis
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Interleukin-17A 导致猪链球菌脑膜炎期间血液-中枢神经系统屏障的破坏
DOI：
10.1007/s12035-022-02749-y
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发表时间：
2022-01
影响因子：
5.1
通讯作者：
Anding Zhang
中科院分区：
文献类型：
--
作者：
Lei Xu;Xi Lu;Peng Xiao;Ran Liu;Kunlong Xia;Meizhou Wu;Meilin Jin;Anding Zhang
猪链球菌（Streptococcus suis，S.是一种新出现的人畜共患病病原体，可导致人类脑膜炎，发病率和死亡率很高。脑膜炎链球菌猪脑膜炎链球菌可诱导产生比非脑膜炎链球菌更高水平的IL-17。猪。此外，IL-17 A通过下调和重组紧密连接（TJ）分子在细菌清除或破坏血液-CNS屏障中发挥各种作用。然而，IL-17 A在脑膜炎链球菌感染中的作用仍有待阐明。猪。在这里，我们发现脑膜炎S。猪传染病不仅可引起多器官损害而急性死亡，而且可在持续菌血症后穿透血-中枢神经系统屏障，从感染后60 h开始出现脑膜炎和临床神经症状。而IL 17 a基因缺陷小鼠的急性炎症反应和急性死亡均无明显改变，但未出现明显的脑膜炎和脑膜炎性链球菌引起的临床神经症状。猪感染。此外，我们还发现，IL-17 A可以抑制TJ蛋白的转录和表达，促进血-CNS屏障的泄漏，从感染后60 h开始，在脑膜炎S。猪感染。因此，我们的研究结果表明，IL-17 A可以下调TJ蛋白，这无疑是促进细菌入侵的血-CNS屏障的泄漏，从而导致S。为今后该病的防治提供了潜在的靶点。
Streptococcus suis (S. suis) is an emerging zoonotic agent that can cause meningitis in humans with high mortality and morbidity. Meningitic S. suis can induce higher level of IL-17 than non-meningitic S. suis. Besides, IL-17A plays various roles on bacterial clearance or disruption of blood-CNS barriers through the downregulation and reorganization of tight junction (TJ) molecules. However, it remains to be elucidated for the role of IL-17A on the infection with meningitic S. suis. Here, we found that meningitic S. suis infection could not only cause acute death due to the damage of multiple organs, but also cause meningitis and clinical nervous signs since 60 h of post-infection due to the penetration of blood-CNS barriers after lasting bacteremia. In contrast, the mice with deficiency of il17a gene could not significantly change the acute inflammatory response and acute death, but it could not show obvious meningitis and clinical nervous signs caused by the meningitic S. suis infection. In addition, we also found that IL-17A could inhibit the transcription and expression of TJ proteins that facilitated the leakage of blood-CNS barriers since 60 h of post-infection during meningitic S. suis infection. Thus, our findings demonstrated that IL-17A could downregulate TJ proteins, which undoubtedly facilitated the leakage of blood-CNS barriers for bacterial invasion and then caused S. suis meningitis, providing potential targets for future prevention and treatment of this disease.
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影响因子：
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作者：
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发表时间：
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影响因子：
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作者：
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影响因子：
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