Weight Loss Directly Influences Intermediate-Term Remission of Diabetes Mellitus After Bariatric Surgery: A Retrospective Case-Control Study.
Weight Loss Directly Influences Intermediate-Term Remission of Diabetes Mellitus After Bariatric Surgery: A Retrospective Case-Control Study.
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DOI：
10.1007/s11695-019-04283-8
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发表时间：
2020-04
期刊：
影响因子：
2.9
通讯作者：
Pralong, F.
中科院分区：
文献类型：
--
作者：
de La Harpe, R.;Rueger, S.;Kutalik, Z.;Ballabeni, P.;Suter, M.;Vionnet, N.;Laferrere, B.;Pralong, F.
关键词：
Roux en Y gastric bypass surgery (RYGB) is an effective therapy for patients with severe obesity. It induces both significant weight loss and rapid improvements of metabolic complications. This study was undertaken to better define the direct role of weight loss in the metabolic improvements. A retrospective, case-control study of a cohort of 649 patients with obesity who underwent RYGB, comparing higher and lower responders at 2 years after surgery (n = 100 pairs). Pairs of patients were matched for age, gender, and initial BMI. The rates of remission of diabetes, hypertension, dyslipidemia, and hyperuricemia were compared using a mixed effects logistic regression analysis. Results Diabetes before surgery was present in 12/100 lower responders and 17/100 higher responders. Remission at 2 years was observed in 4/12 (33%) of lower responders, compared to 15/17 (88%) of higher responders. Thus, the odds of diabetes remission was significantly smaller in lower responders (OR = 0.067, 95% CI 0.01–0.447). A mixed model regression analysis of all the parameters for each patient showed that the odds of achieving remission of any comorbidity was significantly lower in lower responders (OR = 0.62, 95% CI = 0.39–0.97). We could demonstrate that weight loss is a significant determinant of the remission of diabetes 2 years after RYGB. These data underline the importance of weight loss in the benefits of this procedure.
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DOI：
10.1111/dme.13532
发表时间：
2018-03
期刊：
Diabetic medicine : a journal of the British Diabetic Association
影响因子：
--
作者：
Pucci A;Tymoszuk U;Cheung WH;Makaronidis JM;Scholes S;Tharakan G;Elkalaawy M;Guimaraes M;Nora M;Hashemi M;Jenkinson A;Adamo M;Monteiro MP;Finer N;Batterham RL
通讯作者：
Batterham RL
仅在发生大量体重减轻并与减肥幅度相关后，才能观察到胃旁路手术后的外周葡萄糖吸收的改善。
影响因子：
3.2
作者：
Campos, Guilherme M.;Rabl, Charlotte;Peeva, Sofia;Ciovica, Ruxandra;Rao, Madhu;Schwarz, Jean-Marc;Havel, Peter;Schambelan, Morris;Mulligan, Kathleen
通讯作者：
Mulligan, Kathleen
影响因子：
16.2
作者：
通讯作者：
--
DOI：
10.1038/oby.2009.102
发表时间：
2009-09
期刊：
Obesity (Silver Spring, Md.)
影响因子：
--
作者：
Patti ME;Houten SM;Bianco AC;Bernier R;Larsen PR;Holst JJ;Badman MK;Maratos-Flier E;Mun EC;Pihlajamaki J;Auwerx J;Goldfine AB
通讯作者：
Goldfine AB
影响因子：
3.5
作者：
Steven, S.;Carey, P. E.;Taylor, R.
通讯作者：
Taylor, R.