Mechanisms of cell division as regulators of acute immune response
Mechanisms of cell division as regulators of acute immune response
复制标题
细胞分裂作为急性免疫反应调节剂的机制
DOI：
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发表时间：
2014
期刊：
影响因子：
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通讯作者：
P. Hodgkin
中科院分区：
文献类型：
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作者：
A. Kan;P. Hodgkin
急性适应性免疫应答是复杂的，经历静止淋巴细胞的活化、通过细胞分裂和细胞分化的快速扩增、分裂停止和超过95%的新产生群体的最终死亡的阶段。控制的反应是不是中央，但似乎作为一个分布式的过程中，全球模式可靠地出现了大量的自主细胞的集体行为的结果。在这篇综述中，我们强调的证据表明，竞争的细胞内定时过程的基础上分布的个人的命运和控制细胞增殖，停止和损失。这些原则可以在数学模型中捕获，以说明与先前发表的实验观察数据的一致性。
The acute adaptive immune response is complex, proceeding through phases of activation of quiescent lymphocytes, rapid expansion by cell division and cell differentiation, cessation of division and eventual death of greater than 95 % of the newly generated population. Control of the response is not central but appears to operate as a distributed process where global patterns reliably emerge as a result of collective behaviour of a large number of autonomous cells. In this review, we highlight evidence that competing intracellular timed processes underlie the distribution of individual fates and control cell proliferation, cessation and loss. These principles can be captured in a mathematical model to illustrate consistency with previously published experimentally observed data.
影响因子：
2
作者：
De Boer, Rob J.;Perelson, Alan S.
通讯作者：
Perelson, Alan S.