Time-resolved spectroscopy and the determination of photon scattering, pathlength, and brain vascular hemoglobin saturation in a population of normal volunteers
Time-resolved spectroscopy and the determination of photon scattering, pathlength, and brain vascular hemoglobin saturation in a population of normal volunteers
复制标题
时间分辨光谱学以及正常志愿者群体中光子散射、光程和脑血管血红蛋白饱和度的测定
DOI：
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
B. Chance
中科院分区：
文献类型：
--
作者：
David S. Smith;W. Levy;S. Carter;NaiGuang Wang;M. Haida;B. Chance
由于光子散射的存在，确定脑内光吸收与发色团浓度之间的关系非常复杂，使得光路长度难以确定。在目前的研究中，我们应用新开发的相位调制（PMS）和时间分辨（TRS）光谱仪来测定组织散射、路径长度和脑血管血红蛋白饱和度（BVH）。PMS测量是在36名成年人的两个额叶皮层上进行的，使用的是间隔4厘米的光导，并紧紧贴在前额上。TRS测量以5 cm探针分离完成。对于PMS测量，在754和816 nm波长处检测到相移的变化。所有受试者TRS波长均为670 nm，部分受试者额外测量波长为820 nm。在没有血红蛋白的情况下，散射和外推的路径长度由TRS数据确定。这些信息与PMS数据相结合来确定BVH。计算出的饱和度变化系数仅为0.04。这表明散射和路径长度都具有显著的主体间可变性，需要明确确定以适当计算血红蛋白饱和度。
Determining the relationship between light absorption and chromophore concentration in brain is complicated by photon scattering, which makes it difficult to determine pathlength. In the current study we apply newly developed phase modulation (PMS) and time-resolved (TRS) spectrometers to determine tissue scattering, pathlength and brain vascular hemoglobin saturation (BVH). PMS measurements were made from both frontal cortices of 36 adults using light guides separated by 4 cm and tightly placed against the forehead. TRS measurements were done with a 5 cm probe separation. For the PMS measurements, changes in phase shift were detected at 754 and 816 nm wavelengths. For TRS, the wavelength was 670 nm in all subjects, and some subjects had additional measurements made at a wavelength of 820 nm. Scattering and the extrapolated pathlength in the absence of hemoglobin were determined from the TRS data. This information was combined with the PMS data to determine BVH. The coefficient variation for the calculated saturation was only 0.04. This suggests both scattering and pathlength have significant intersubject variability and need to be explicitly determined for appropriate calculation of hemoglobin saturation.
DOI：
10.1073/pnas.85.14.4971
发表时间：
1988-07-01
影响因子：
11.1
作者：
CHANCE, B;LEIGH, JS;BORETSKY, R
通讯作者：
BORETSKY, R
用于确定组织氧合的时间和频率分辨光谱的定量。
影响因子：
2.9
作者：
Sevick,EM;Chance,B;Leigh,J;Nioka,S;Maris,M
通讯作者：
Maris,M