Megakaryocytes, malignancy and bone marrow vascular niches.
Megakaryocytes, malignancy and bone marrow vascular niches.
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DOI：
10.1111/j.1538-7836.2011.04571.x
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发表时间：
2012-02
期刊：
影响因子：
--
通讯作者：
Roberts I
中科院分区：
文献类型：
--
作者：
Psaila B;Lyden D;Roberts I
Dynamic interactions between haematopoietic cells and their specialised bone marrow microenvironments, namely the vascular and osteoblastic ‘niches’ regulate haematopoiesis. The vascular niche is conducive for thrombopoiesis, and megakaryocytes may, in turn, regulate the vascular niche, especially in supporting vascular and haematopoietic regeneration following irradiation or chemotherapy. A role for platelets in tumour growth and metastasis is well established and, more recently, the vascular niche has also been implicated as an area for preferential homing and engraftment of malignant cells. This article aims to provide an overview of the dynamic interactions between cellular and molecular components of the bone marrow vascular niche and the potential role of megakaryocytes in bone marrow malignancy.
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影响因子：
11.2
作者：
Caunt, M;Hu, L;Karpatkin, S
通讯作者：
Karpatkin, S
DOI：
10.1083/jcb.138.3.707
发表时间：
1997-08-11
期刊：
The Journal of cell biology
影响因子：
--
作者：
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Bouck NP
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作者：
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Sipkins, Dorothy A.
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通讯作者：
Kacena, Melissa A.
影响因子：
15.9
作者：
Dias, S;Hattori, K;Rafii, S
通讯作者：
Rafii, S