Single-cell insights into the hematopoietic generation of T-lymphocyte precursors in mouse and human.
Single-cell insights into the hematopoietic generation of T-lymphocyte precursors in mouse and human.
复制标题
单细胞对小鼠和人造血t淋巴细胞前体生成的见解。
DOI：
10.1016/j.exphem.2020.12.005
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发表时间：
2021-03
影响因子：
2.6
通讯作者：
Rothenberg EV
中科院分区：
文献类型：
--
作者：
Rothenberg EV
T细胞发育是淋巴发育的主要分支，也是造血的关键输出，特别是在生命早期，但T细胞潜能的分子要求仍然不清楚。现在已经取得了相当大的进展，通过单细胞转录组研究解决这个问题，与体外分化测定，有效地监测潜力，在单细胞水平。本文综述了最近的一系列研究小鼠和人类早期T细胞前体的报告，无论是在发育中的胎儿和严格纯化的出生后样本的胸腺内和胸腺前T-谱系前体。结果的交叉比较显示，在小鼠和人类的一个稳健保守的核心程序，但与物种之间和个体发育状态之间的一些信息和挑衅性的变化。重复的发现是胸腺接种细胞的多能祖细胞调节特征和T细胞程序与树突状细胞程序的接近性，特别是人类中的浆细胞样树突状细胞。
T cell development is a major branch of lymphoid development and a key output of hematopoiesis, especially in early life, but the molecular requirements for T-cell potential have remained obscure. Considerable advances have now been made toward solving this problem through single-cell transcriptome studies, interfaced with in vitro differentiation assays that monitor potential efficiently at the single cell level. This review focuses on a series of recent reports studying mouse and human early T cell precursors, both in the developing fetus and in stringently purified postnatal samples of intrathymic and prethymic T-lineage precursors. Cross-comparison of results shows a robustly conserved core program in mouse and human, but with some informative and provocative variations between species and between ontogenic states. Repeated findings are the multipotent progenitor regulatory signature of thymus-seeding cells and the proximity of the T cell program to dendritic cell programs, especially to plasmacytoid dendritic cells in humans.
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影响因子：
30.5
作者：
Casero D;Sandoval S;Seet CS;Scholes J;Zhu Y;Ha VL;Luong A;Parekh C;Crooks GM
通讯作者：
Crooks GM
影响因子：
64.8
作者：
ARDAVIN, C;WU, L;SHORTMAN, K
通讯作者：
SHORTMAN, K
影响因子：
32.4
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通讯作者：
Rodewald, Hans-Reimer
影响因子：
7.7
作者：
Dolens, Anne-Catherine;Durinck, Kaat;Taghon, Tom
通讯作者：
Taghon, Tom
影响因子：
46.9
作者：
Fischer, David S.;Fiedler, Anna K.;Theis, Fabian J.
通讯作者：
Theis, Fabian J.