Focal changes in brain energy and phospholipid metabolism in first-episode schizophrenia
Focal changes in brain energy and phospholipid metabolism in first-episode schizophrenia
复制标题
首发精神分裂症脑能量和磷脂代谢的局灶性变化
DOI：
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发表时间：
2004
影响因子：
10.5
通讯作者：
D. Drost
中科院分区：
文献类型：
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作者：
J. Jensen;Jodi E. Miller;P. Williamson;R. Neufeld;Ravi S. Menon;A. Malla;R. Manchanda;B. Schaefer;M. Densmore;D. Drost
背景：用磷磁共振波谱（31 P-MRS）测量的膜磷脂和高能量异常已被报道在精神分裂症患者的几个脑区。目的采用改进的成像技术，对首发精神分裂症患者和健康志愿者的脑组织进行4. 0 T31 P-MRS检查。方法采集15例首发精神分裂症患者和15例健康志愿者的脑组织，采集丘脑、小脑、海马、前/后扣带回、前/后扣带回、前额皮质和顶枕皮质。结果首发精神分裂症患者前扣带回甘油磷酸胆碱水平增高。无机磷酸盐，磷酸肌酸和腺苷三磷酸浓度也增加了前扣带回在这一组。结论首发精神分裂症患者大脑前扣带回磷酸二酯和高能磷酸盐水平升高可能表明该区域在疾病早期存在神经过度活动，导致兴奋性毒性神经膜破裂增加。
Background Membrane phospholipid and high-energy abnormalities measured with phosphorus magnetic resonance spectroscopy (31P-MRS) have been reported in patients with schizophrenia in several brain regions. Aims Using improved imaging techniques, previously inaccessible brain regions were examined in patients with first-episode schizophrenia and healthy volunteers with 4.0 T 31P-MRS. Method Brain spectra were collected in vivo from 15 patients with first-episode schizophrenia and 15 healthy volunteers from 15 cm3 effective voxels in the thalamus, cerebellum, hippocampus, anterior/posterior cingulate, prefrontal cortex and parieto-occipital cortex. Results People with first-episode schizophrenia showed increased levels of glycerophosphocholine in the anterior cingulate. Inorganic phosphate, phosphocreatine and adenosine triphosphate concentrations were also increased in the anterior cingulate in this group. Conclusions The increased phosphodiester and high-energy phosphate levels in the anterior cingulate of brains of people with first-episode schizophrenia may indicate neural overactivity in this region during the early stages of the illness, resulting in increased excitotoxic neural membrane breakdown.
影响因子：
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作者：
Andreasen, NC
通讯作者：
Andreasen, NC