The regulation of self-tolerance and the role of inflammasome molecules.
The regulation of self-tolerance and the role of inflammasome molecules.
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DOI：
10.3389/fimmu.2023.1154552
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发表时间：
2023
影响因子：
7.3
通讯作者：
中科院分区：
文献类型：
--
作者：
炎症体分子组成一个受体家族，通常在被微生物病原体感染时启动促炎反应。炎症体活动的失调与不必要的慢性炎症有关，这也与某些自身免疫性疾病有关，如多发性硬化症、类风湿性关节炎、1型糖尿病、系统性红斑狼疮以及相关的动物模型。经典的炎症体激活依赖事件对固有免疫效应器和获得性免疫效应器以及靶组织中的驻留细胞都有内在和外在的影响，这些都可以促进自身免疫反应。最近还发现，炎症体分子可以独立于经典的炎症体激活炎症来调节免疫效应细胞的分化和功能。炎症体分子的这些替代功能塑造了适应性免疫反应的性质，反过来可以促进或抑制自身免疫的进展。在这篇综述中，我们将对炎症体分子在调节自身耐受和自身免疫发展中的作用进行综述。
Inflammasome molecules make up a family of receptors that typically function to initiate a proinflammatory response upon infection by microbial pathogens. Dysregulation of inflammasome activity has been linked to unwanted chronic inflammation, which has also been implicated in certain autoimmune diseases such as multiple sclerosis, rheumatoid arthritis, type 1 diabetes, systemic lupus erythematosus, and related animal models. Classical inflammasome activation-dependent events have intrinsic and extrinsic effects on both innate and adaptive immune effectors, as well as resident cells in the target tissue, which all can contribute to an autoimmune response. Recently, inflammasome molecules have also been found to regulate the differentiation and function of immune effector cells independent of classical inflammasome-activated inflammation. These alternative functions for inflammasome molecules shape the nature of the adaptive immune response, that in turn can either promote or suppress the progression of autoimmunity. In this review we will summarize the roles of inflammasome molecules in regulating self-tolerance and the development of autoimmunity.
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影响因子：
56.9
作者：
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通讯作者：
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影响因子：
3.2
作者：
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通讯作者：
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DOI：
10.1073/pnas.1508740112
发表时间：
2015-08-11
影响因子：
11.1
作者：
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通讯作者：
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影响因子：
5.4
作者：
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通讯作者：
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