Lipocalin 2: a multifaceted modulator of human cancer.
Lipocalin 2: a multifaceted modulator of human cancer.
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DOI：
10.4161/cc.8.15.9224
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发表时间：
2009-08
期刊：
影响因子：
--
通讯作者：
Moses MA
中科院分区：
文献类型：
--
作者：
Yang J;Moses MA
脂质运载蛋白2（Lcn2）是脂质运载蛋白家族中携带小的亲脂性配体的成员，作为人类癌症的潜在生物标志物和调节剂，最近受到关注。在这里，我们描述了最近的研究结果LCN 2在乳腺癌中的功能和潜在的机制，其行动的基础。已显示Lcn2诱导乳腺癌细胞中的上皮向间充质转化（EMT）并促进乳腺肿瘤侵袭。雌激素受体α可能参与了Lcn2诱导EMT的途径。初步证据还表明，Lcn2可用作乳腺癌的潜在非侵入性尿液生物标志物。在其他人类癌症中也报道了Lcn2水平升高。Lcn2在其他一些上皮性肿瘤以及白血病中的潜在作用也在这里进行了审查和讨论。
Lipocalin 2 (Lcn2), a member of the lipocalin family that carries small lipophilic ligands, has gained recent attention as both a potential biomarker and a modulator of human cancers. Here we describe recent findings of the functions of Lcn2 in breast cancer and the potential mechanisms that underlie its actions. Lcn2 has been shown to induce the epithelial to mesenchymal transition (EMT) in breast cancer cells and to promote breast tumor invasion. Estrogen receptor α may participate in the pathway that leads to Lcn2-induced EMT. Preliminary evidence also suggests that Lcn2 may be used as a potential non-invasive urinary biomarker of breast cancer. Elevated levels of Lcn2 have also been reported in other human cancers. The potential roles of Lcn2 in some other epithelial tumors as well as leukemia are also reviewed and discussed here.
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影响因子：
3.5
作者：
Hvidberg, V;Jacobsen, C;Borregaard, N
通讯作者：
Borregaard, N
DOI：
10.1073/pnas.0510847103
发表时间：
2006-02-07
影响因子：
11.1
作者：
Berger, T;Togawa, A;Mak, TW
通讯作者：
Mak, TW
影响因子：
16
作者：
Goetz, DH;Holmes, MA;Strong, RK
通讯作者：
Strong, RK
影响因子：
4.5
作者：
Hull-Thompson J;Muffat J;Sanchez D;Walker DW;Benzer S;Ganfornina MD;Jasper H
通讯作者：
Jasper H
影响因子：
64.5
作者：
Devireddy, LR;Gazin, C;Green, MR
通讯作者：
Green, MR