eIF-Three to Tango: emerging functions of translation initiation factor eIF3 in protein synthesis and disease
eIF-Three to Tango: emerging functions of translation initiation factor eIF3 in protein synthesis and disease
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eIF-Three to Tango：翻译起始因子 eIF3 在蛋白质合成和疾病中的新功能
DOI：
10.1093/jmcb/mjaa018
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发表时间：
2019-06
影响因子：
5.5
通讯作者：
Yabin Cheng
中科院分区：
文献类型：
--
作者：
Dieter A. Wolf;Yingying Lin;Haoran Duan;Yabin Cheng
摘要近三年来的研究大大扩展了真核生物起始因子3（eIF3）在信使RNA（mRNA）翻译中的作用。现在看来，这种多亚基复合物参与了mRNA翻译的每一种可能形式，以积极和消极的方式控制蛋白质合成的每一步，从起始到延伸，终止和质量控制。通过对eIF3的研究，我们开始认识到蛋白质合成是一个高度整合的过程，它协调蛋白质的产生、蛋白质的折叠、亚细胞靶向和降解。同时，eIF3亚基似乎具有特定的功能，可能在不同组织和单个细胞之间存在差异。考虑到eIF3在蛋白质稳态中的广泛功能，eIF3越来越多地参与重大人类疾病并首次尝试治疗靶向eIF3并不令人惊讶。然而，关于eIF3在蛋白质合成和疾病中的亚基和组织特异性功能及其受环境条件和翻译后修饰的调节，还有很多东西有待了解。
Abstract Studies over the past three years have substantially expanded the involvements of eukaryotic initiation factor 3 (eIF3) in messenger RNA (mRNA) translation. It now appears that this multi-subunit complex is involved in every possible form of mRNA translation, controlling every step of protein synthesis from initiation to elongation, termination, and quality control in positive as well as negative fashion. Through the study of eIF3, we are beginning to appreciate protein synthesis as a highly integrated process coordinating protein production with protein folding, subcellular targeting, and degradation. At the same time, eIF3 subunits appear to have specific functions that probably vary between different tissues and individual cells. Considering the broad functions of eIF3 in protein homeostasis, it comes as little surprise that eIF3 is increasingly implicated in major human diseases and first attempts at therapeutically targeting eIF3 have been undertaken. Much remains to be learned, however, about subunit- and tissue-specific functions of eIF3 in protein synthesis and disease and their regulation by environmental conditions and post-translational modifications.
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影响因子：
16
作者：
Sha, Zhe;Brill, Laurence M.;Cabrera, Rodrigo;Kleifeld, Oded;Scheliga, Judith S.;Glickman, Michael H.;Chang, Eric C.;Wolf, Dieter A.
通讯作者：
Wolf, Dieter A.
N6-甲基腺苷驱动的环状 RNA 的广泛翻译。
影响因子：
44.1
作者：
Yang Y;Fan X;Mao M;Song X;Wu P;Zhang Y;Jin Y;Yang Y;Chen LL;Wang Y;Wong CC;Xiao X;Wang Z
通讯作者：
Wang Z
影响因子：
14.9
作者：
Eliseev B;Yeramala L;Leitner A;Karuppasamy M;Raimondeau E;Huard K;Alkalaeva E;Aebersold R;Schaffitzel C
通讯作者：
Schaffitzel C
影响因子：
14.9
作者：
Wagner S;Herrmannová A;Šikrová D;Valášek LS
通讯作者：
Valášek LS
真核翻译起始因子3（EIF3）亚基E对于胚胎发育和细胞增殖至关重要。
影响因子：
2.6
作者：
Sadato D;Ono T;Gotoh-Saito S;Kajiwara N;Nomura N;Ukaji M;Yang L;Sakimura K;Tajima Y;Oboki K;Shibasaki F
通讯作者：
Shibasaki F