Obstetrical Complications in Women with Endometriosis: A Cohort Study in Japan.
Obstetrical Complications in Women with Endometriosis: A Cohort Study in Japan.
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DOI：
10.1371/journal.pone.0168476
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Japan Environment & Children’s Study Group
中科院分区：
文献类型：
--
作者：
Harada T;Taniguchi F;Onishi K;Kurozawa Y;Hayashi K;Harada T;Japan Environment & Children’s Study Group
子宫内膜异位症，发生在大约10%的育龄妇女，被定义为子宫外存在子宫内膜组织。患有子宫内膜异位症的女性更有可能难以受孕，并倾向于接受不孕治疗，包括辅助生殖技术（ART）治疗。目前还没有一个前瞻性队列研究检查子宫内膜异位症对日本孕妇妊娠结局的影响。这是一项使用日本环境与儿童研究（JECS）数据的子宫内膜异位症妇女产科并发症发生率的前瞻性队列研究。本研究纳入了JECS中的9，186名有或没有子宫内膜异位症病史的孕妇，这些孕妇在2011年2月至12月期间分娩或死产或因流产而终止妊娠。子宫内膜异位症对妊娠结局的影响在JECS中的9，186名孕妇中，4，119名（44.8%）患有产科并发症; 330名参与者在怀孕前报告了子宫内膜异位症的诊断，这些妇女的妊娠并发症风险高于没有子宫内膜异位症病史的妇女（比值比（OR）= 1.50; 95%置信区间（CI）1.20至1.87）。Logistic回归分析显示，有子宫内膜异位症病史的自然受孕孕妇产科并发症的调整OR为1.45（CI 1.11 ~ 1.90）。在子宫内膜异位症孕妇中，早产胎膜早破（PROM）和前置胎盘的OR显著高于从未诊断为子宫内膜异位症的妇女，这些妇女自然受孕或在不孕治疗后受孕，ART治疗除外（OR 2.14，CI 1.03-4.45和OR 3.37，CI 1.32-8.65）。这项研究表明，在调整ART治疗数据的混杂因素后，子宫内膜异位症显著增加了早产胎膜早破和前置胎盘的发生率。
Endometriosis, which occurs in approximately 10% of women of reproductive age, is defined as the presence of endometrial tissue outside the uterus. Women with endometriosis are more likely to have difficulty conceiving and tend to receive infertility treatment, including assisted reproductive technology (ART) therapy. There has not yet been a prospective cohort study examining the effects of endometriosis on pregnancy outcome in pregnant Japanese women. This was a prospective cohort study of the incidence of obstetrical complications in women with endometriosis using data of the Japan Environment & Children’s Study (JECS). Included in this study were 9,186 pregnant women in the JECS with or without a history of endometriosis who gave birth or stillbirth or whose pregnancy was terminated with abortion between February and December 2011. The effects of endometriosis on pregnancy outcome. Of the 9,186 pregnant women in the JECS, 4,119 (44.8%) had obstetrical complications; 330 participants reported a diagnosis of endometriosis before pregnancy, and these women were at higher risk for complications of pregnancy than those without a history of endometriosis (odds ratio (OR) = 1.50; 95% confidence interval (CI) 1.20 to 1.87). Logistic regression analyses showed that the adjusted OR for obstetrical complications of pregnant women who conceived naturally and had a history of endometriosis was 1.45 (CI 1.11 to 1.90). Among pregnant women with endometriosis, the ORs of preterm premature rupture of the membranes (PROM) and placenta previa were significantly higher compared with women never diagnosed with endometriosis who conceived naturally or conceived after infertility treatment, except for ART therapy (OR 2.14, CI 1.03–4.45 and OR 3.37, CI 1.32–8.65). This study showed that endometriosis significantly increased the incidence of preterm PROM and placenta previa after adjusting for confounding of the data by ART therapy.
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影响因子：
6.1
作者：
Stephansson, Olof;Kieler, Helle;Falconer, Henrik
通讯作者：
Falconer, Henrik
DOI：
10.1055/s-2007-1016334
发表时间：
1996-08-01
期刊：
SEMINARS IN REPRODUCTIVE ENDOCRINOLOGY
影响因子：
--
作者：
Osteen, KG;Bruner, KL;Sharpe-Timms, KL
通讯作者：
Sharpe-Timms, KL
影响因子：
2.1
作者：
Kortelahti, M;Anttila, MA;Heinonen, ST
通讯作者：
Heinonen, ST
影响因子：
2.1
作者：
Pizzo, A;Salmeri, FM;Marsico, S
通讯作者：
Marsico, S
DOI：
10.1111/j.1447-0756.2011.01653.x
发表时间：
2011-09-01
影响因子：
1.6
作者：
Minakami, Hisanori;Hiramatsu, Yuji;Yoshikawa, Hiroyuki
通讯作者：
Yoshikawa, Hiroyuki